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Calicheatino cov leeg tshuaj tua kab mob cannioticiot

Calicheatino cov leeg tshuaj tua kab mob cannioticiot

Lub Npe Lus Askiv: CalichiSin
Tus lej lej: 108212-75-5
Lwm lub npe:
calicheamicin gamma(1)I; Benzenecarbothioic acid, 4-((6-deoxy-3-o-methyl-alpha-L-mannopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methyl-, 4''-ester with methyl (8-((4,6-dideoxy-2-o-(2,4-dideoxy-4-(ethylamino)-3-o-methyl-alpha-L-threo-pentapyranosyl)-4-(((2,6-dideoxy-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-beta-D-glucopyranosyl)oxy)-1-hydroxy-13-(2-(methyltrithio)ethylidene)-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)carbamate, (1R-(1R*,4Z,8S*,13E))-; Calichemicin gamma1; Carbamic acid, ((1R,4Z,8S,13E)-8-((4,6-dideoxy-4-(((2,6-dideoxy-4-S-(4-((6-deoxy-3-o-methyl-alpha-L-mannopyranopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methylbenzoyl)-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-2-o-(2,4-dideoxy-4-(ethylamino)-3-o-methyl-alpha-L-threo-pentopyranosyl)-beta-D-glucopyranosyl)oxy)-1-hydroxy-13-(2-(methyltrithio)ethylidene)-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)-, methyl ester; Calicheamicin γ1; LL-E 33288 gamma1-I; calicheamicin gamma; Calicheamicin γ1 purity>95
Xa kev nug

Cov khoom lag luam

 

Hmong npe: Calichmerin

Tus lej lej: 108212-75-5

Molecular Cov Qauv: C55H74in3O21s4

Molecular hnyav: 1,368.34

Einecs tsis muaj:

Lwm yam pawg: API [rau kev tshawb fawb txuj ci tshwj xeeb]; Kws API; Kev Tshawb Fawb Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Siv Tshuaj; API; API thiab intermediates; reagents; lwm tus; tshuaj lom neeg tshuaj lom neeg; ADC; Chaw ua tshuaj paus

Cov Mol ntaub ntawv: 108212-75-5. Mol

 

Molecular qauv:

1 -

 

Calithromycin Cov Khoom Siv

Kev sib hloov tshwj xeeb: D 26-124 (c=0. 98%, etoh)

Ceev: 1.57 {{0. 1 g / cm3 (kwv yees)

Kev Cia Cov Neeg Tiv Thaiv: Khw ntawm -20 c

Solubility: DMOs: 100 MG / ML (73.08 hli); Dej:<0.1 mg / mL (insoluble)

Daim Ntawv: Khoom

Cov kab mob coefficient (pk a): 7.13 ± 0. 60 (kwv yees)

Xim: dawb rau daj

 

Siv thiab Synthesis txoj kev ntawm Calicimamycin

 

Cov lus qhia luv luv

CalichleSamicins (Clm) yog Enediyne Antiyne Antiyne Antiyne Antiyne Antiyre Anti-Cov Qaum Cais

 

Mechanism ntawm Kev Ua

Cov khoom siv sib xyaw ntawm carchithromycin<1 PgmL-1 had extremely potent killing effects in leukemia such as lymphocytic leukaemia P388 and L1210 cells as well as solid tumors such as colon cancer 26 and melanoma B-16 cells. The biological activity of cazithromycin mainly by combining cellular DNA with the Chemicalbook minor groove, directly break cell DNA, further induce tumor cell apoptosis, at the same time, cazithromycin has nonspecific damage effect on cellular RNA, Mylotarg with CD33 monoclonal antibody conjugate is the first approved by the FDA for tumor treatment, has been used in clinical practice.

 

Kev siv

Cchathromycin yog tus sawv cev cytotoxic uas tuaj yeem ua rau DNA ob chav strand tawg.

 

Lom zem

Cachithromycin yog cov tshuaj lom thiab yog ib ntawm ntau pua ntawm cov metabolites ua los ntawm cov kab mob av.

 

Bioactivity

Calichneamicin yog cov tshuaj tua kab mob qog nqaij thiab kuj muaj lub zog cytotoxic tus neeg sawv cev, ua rau DNA ob chav-strand tawg. Calicheatin inhibition ntawm DNA synthesis.

 

Phiaj Xwm

Calichmicins

 

Hauv kev kawm vitro

Pf {{{{{{{{{{{{}}} (wb}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} -calichicin - 1 hacktawv-PayloadwithanaveraDa (DAR) of4.6.pf {{elicitsa ntigen-favoncentration-basentcytciTotoxicity, asexposuretopf {16}}}}}} bookctiveinparintriceprimararyb-celleprecursorac mobmoblastelasteLavro.cmc {24} {lettime-{ Om0.15to4.9ng / ml.clc {32 s}} (10ng / mL / mL / mL / mL / mL / mL / mL / {ujcellarys.inclcc {35} Trea Tedcells, thelevelofcd22hasdecreastrelatatiatong5 / 44- kev kho mob ntawm kev kho mob.

 

Hauv Vivo Tshawb Fawb

Anadcomprisingahumanized A-EFNA4MONIOCLONALANTANCONALANTUALYONDAGENTOKEDNYEAMICICHINIVEUSTAORREGORREGORREGREFEGORREGREFEGREFEGORREGREFEGREGREGREGINAL Bookressionsinbothtnothtnbrascancerpdxinvivo. 27, {} ({}. 27}}. 27,}. 27,}. 27,}. 27,}. 27,}. 27,}. 27,}. 27,}.

 

Cim npe nrov: Costheatmanicin Cov Tshuaj Tiv Thaiv Calichioty CyTotoxic, Tuam Tshoj Calichneamicin Cov Lus Tus Tshuaj Tiv Thaiv