Infliximab yog tus ntsuas roj monoclonal igg1 antibody

English Lub Npe: Infliximab

Tus lej lej: 170277-31-3

Molecular Cov Qauv

Molecular hnyav: 0

Einecs tsis muaj

Lwm yam ntawm: Mab 12; Tswj khoom; Tshuaj Nplaum Xov Xwm

Cov Mol Cov Ntaub Ntawv: MOL cov ntaub ntawv

Cov Qauv Txheej Txheem:

Xwm ntawm infliximab cov thawj coj

Kev Cia Cov Neeg Tiv Thaiv: Khw ntawm -30 c

Daim Ntawv: Khoom

Xim: Dawb rau off-dawb

Bioactivity

Infliximab (Avakine) yog tus ntsuas roj monoclonal igg 1 tshuaj tiv thaiv uas khi tshwj xeeb rau TNF-. Tiv thaiv qhov kev sib cuam tshuam ntawm tnfchemicalbook- nrog tnf- receptor 1 (tnfr2 (tnfr2) thiab tnfr2. Cov kab mob ntawm autoimmune,

Phiaj Xwm

Tnf-

Hauv kev kawm vitro

TNF - -}} Kho cov adipocytes qhia tau tias muaj txiaj ntsig zoo, 10 ng / mL) Infliximab restores phosphorylation ntawm substrate {8}} thiab akt los ntawm attautating protein-tyrosine phospatase 1b (ptp1b) ua kom muaj zog. Infliximab ameliorates tnf {12}}}}}}}}}} Cov tshuaj insulin tsis kam nyob rau hauv cov khoom lag luam insulin ntawm ptp1b inhibition.

Hauv Vivo Tshawb Fawb

Ib qho kev txhaj tshuaj ntawm infliximab (10 ug / g nyob rau hauv 100 ultrine / dose} / +) kev tiv thaiv hluav taws xob ntau ntxiv rau 4 lub lis piam. Qhov nce TNF- MRNA qhia nyob rau hauv cov ntshav qab zib dorsal dorsal dorsal paus ganglion yog tseem muaj zog los ntawm infliximab.

Cov Ntaub Ntawv Seev Cev

Cov ntaub ntawv lom neeg cov ntaub ntawv: {170277-31-3 (cov ntaub ntawv muaj kev phom sij)

Cim npe nrov: Infliximab yog tus ntsuas roj monoclonal igg1 antibody, Tuam Tshoj infliximab yog ib tug chimeric monoclonal igg1 tshuaj tiv thaiv kab mob