Hlau sucrose ntxiv

Lub Npe Lus Askiv: Hlau Saccharate

Tus lej lej: 8047-67-4

Molecular cov mis: c18h24fe2o24

Molecular hnyav: 736.06

Einecs tus naj npawb: 232-464-7

Lwm Qeb

Monosaccharides; Cov ntaub ntawv rawcuitical; Cov ntaub ntawv rawcuitical; Siv tshuaj lom neeg roj ntsha; Cov ntaub ntawv raw; Lwm cov khoom lag luam tshuaj; Cov Khoom Siv Raw Tshuaj; API; carbohydrates & derivatives; Intermediates & zoo tshuaj lom neeg; Kws Tshuaj

Mol Cov Ntaub Ntawv: 8047-67-4. Mol

Cov Qauv Txheej Txheem:

Hlau Sucrose Khoom

Melting taw tes: 168-171 degree

Cov Khoom Noj Khoom Haus: Tub Yees

Solubility: me ntsis soluble hauv dej

Daim Ntawv: Khoom

Xim: Xim av rau xim av tsaus

Inchi: Inchi =1 / 3C6h10o8.2Fe / C3 * {; / / h3 * {21}}, { 22}} h, (h, 11,12) (h, 13,14) ;;; {{{{{}}}}}}}}} ;; / s3

Inchikey: Adqsudsbzbmmmmmmmmmmmmm4dlna-h

CAS database: 8047-67-4 (CASTE)

(Iarc) carcinogen faib: 3 (vol. 2, sup 7) 1987epa

Cov Lus Qhia Tshuaj: Hlau Saccharate (8047-67-4)

Txhawb Nqa Hlau Txhawb Nqa

Hlau Sucrose tau siv cov neeg txawv teb chaws tau ntau xyoo, thiab tau ua lag luam hauv 68 lub tebchaws thiab cov cheeb tsam kev txhaj tshuaj yog qhov qub ntawm cov khoom siv hlau uas tau siv. Iron sucrose txhaj hauv kev kho cov tshuaj tsis taus hlau tsis muaj peev xwm txhawb kev nkag nrawm nrawm, uas yog qhov tseem ceeb rau erythropoiesis. Kev Txhaj Tshuaj ntawm Hlau sucrose kev txhaj tshuaj yog ib qho ntawm cov kev siv tshuaj tiv thaiv kev kho mob feem ntau. Piv nrog qhov ncauj ferrous succinate, qhov teeb meem nqus ntawm cov hlau zoo dua, thiab cov tsos mob plab hnyuv tsis yooj yim tshwm sim. Piv nrog lwm hom tshuaj cov tshuaj tiv thaiv kab, hlau soob, nws cov kev mob hlau ntxiv xws li cov khoom siv tshuaj txhuam hniav ntxiv rau hauv cov khoom lag luam hlau ntxiv. Ib qho ntxiv, txoj kev tshawb fawb pom tias cov neeg mob ntshav qab zib los ntawm kev kho cov tshuaj tiv thaiv hlau tuaj yeem muaj cov kws kho mob zoo tshaj plaws ntawm cov neeg mob, thiab yog tsim nyog ua haujlwm thiab kev thov.

Iron sucrose txhaj yog ib qho tshuaj zoo rau kev kho cov tshuaj tsis txaus ntseeg, thiab nws tau ua tiav cov kev kho mob zoo li cov tshuaj tua hluav taws xob hauv kev kho mob.

Txiav txim siab

Tus neeg siv hlau yog qhov tsim nyog rau cov neeg uas yog tus tsis haum rau cov kab mob ntawm qhov ncauj lossis cov uas tsis zoo nqus ntawm qhov ncauj hlau. Yog tias koj txhaj nws ncaj qha, koj tuaj yeem pab txhawb hlau rau tib neeg lub cev. Dab tsi ntxiv, nws yuav tsum tau sau tseg tias thaum peb siv txhaj tshuaj, cov qauv kev lis ntshav hauv qab no feem ntau muaj kev hloov pauv ntawm cov saline ib txwm. Nkag siab txog cov ntshav kev poob lossis cov hlau uas xav tau ntxiv, thiab lwm yam., Tom qab xam, siv nws raws li kws kho mob cov kev taw qhia. Tswj kev txhaj tshuaj ceev thaum siv hlau sucrose txhaj tshuaj, yog tias kev txhaj tshuaj nrawm heev, nws yuav ua rau hypoglycemia.

Sab qaum

Anemia yog qhov teeb meem tseem ceeb ntawm lub raum rau cov raum tsis ua haujlwm, thiab cov neeg mob lim dej kom zoo dua rau cov neeg mob erythropoietin tsis yog lossis muaj kev ua haujlwm tsis zoo. Hlau tsis txaus yog qhov ua rau muaj ererthropoietin tsis kam, thiab tsim nyog hlau ntxiv yog qhov tseem ceeb uas tau txais kev ua tau zoo ntawm erythrodoietin. Muaj ob txoj hauv kev los ntxiv cov hlau, qhov ncauj thiab lub qhov ncauj. Cov neeg mob uas tseem muaj anemia moder Tom qab kev tswj hwm lub qhov ncauj ntev ntev ntev thiab cov ntshav qab ntawm HB hauv lub raum hloov kho txawm tias kev siv hluav taws xob ib txwm muaj erythropoietin. Ua ntej siv cov hlau entravenous, feem coob ntawm cov neeg mob muab cov neeg mob ntawm qhov ncauj hlau. Cov kev tshawb fawb tau pom tias qhov ncauj tshuaj ntxuav tau yog qhov nyuaj kom ua tiav lossis tswj hwm lub hom phiaj kho ntawm lub raum tsis zoo. Cov laj thawj yuav muaj: tsis txaus, qhov nruab nrab txhua hnub ntawm cov hlau tsuas yog 10 rau 15mg, thiab tsuas yog 10% ntawm nws tuaj yeem nqus tau; Kev ua kom ploj heev, xws li kev kuaj ntshav ntau dhau, cov ntshav uas tseem muaj cov ntshav hauv lub nkoj thiab cov raj dej, txoj hnyuv los ntshav, thiab lwm yam .; Daim ntawv thov ntawm Rhepo nce qhov kev thov rau cov hlau hauv lub cev.

Ntau thiab ntau cov kev tshawb fawb tau qhia tias cov hlau nthuav tawm tuaj yeem txhim kho cov neeg mob ntawm Hemodialysis yuav tsum tau muab cov neeg mob hlau ua kom zoo dua los kho anemia. Iron sucrose hlau hydroxide (ⅲ) -sucrose kev siv ntawm daim quav kab mob kas fes, thiab mob hempobin thiab hcchemicals tau nce ntxiv. Yog li no, kev txhaj tshuaj hlau yog qhov ua tau zoo dua hauv kev kho kom zoo nkauj tshaj qhov ncauj hlau. Iron sucrose yog tus neeg saib xyuas hlau muaj kev nyab xeeb tshaj plaws ntawm tam sim no. Nws muaj qhov zoo ntawm kev ua yeeb yam ceev ceev, tsis yooj yim kev ua xua thiab siv hlau ua xua. Nws yog dav siv hauv chaw kho mob. Tom qab cov tshuaj tiv thaiv hlau ntxiv, tus neeg saib xyuas hlau khi rau cov hlwb pob txha, uas tuaj yeem ceev ceev cov pob txha hlau, tswj hwm cov neeg mob

Pharmacological txiav txim siab

Iron sucrose yog polykuclefl ferric hydroxide (III), txoj kev sib txuas ntawm cov khoom sib txuas lus sib txawv, ua ke nrog qhov hnyav molecular phaus ntawm 43kda. Cov qauv macromolecular no tuaj yeem zam tsis txhob raug tshem tawm los ntawm lub raum. Cov complex yog kev ruaj ntseg ruaj khov thiab tso cov hlau ions raws li cov kev mob tsim nyog.

Pharmaconinetics

Kev nqus tau: Ib qho koob tshuaj uas muaj 100mg ntawm cov khoom no tau mus txog qib siab tom qab 10min, kev ntsuas 538μμLol / l.

Faib: Ceg Central Dispecting ntim yog li ntawm 3L, thiab lub xeev xa tawm ruaj khov yog li 8l.

Cov metabolism thiab ua kom tiav: Cov hlau txhaj tawm sai sai tshem tawm hauv cov ntshav, nrog ib nrab-lub neej ntawm kwv yees li 6h; Kev tshem tawm hlau tau tsawg dua 5% ntawm tag nrho cov kev tshem tawm 4 teev ua ntej txhaj tshuaj, thiab kwv yees li 75% ntawm sucrose tau ua tiav tom qab 24 teev.

Kev taw tes

Nws yog cov kho mob ntawm kev kho mob ntawm cov hlau tsis txaus ntseeg uas tsis muaj peev xwm ua tau zoo ntawm cov hlau tsis txaus, xws li cov tshuaj nqus tsis zoo thiab cov kab mob ntawm lub ncauj nqus dej.

Kev npaj

Txoj Kev 1: Ferric hydroxide colloids tau npaj los ntawm cov tshuaj tiv thaiv ntawm ferric ntsev thiab inorganic puag ntawm 5 ~ 20 degree. Ferric hydroxide colloids yog ces nyuaj nrog sucrose ntawm 100 ~ 120 degree kom tau ferric serric derrose tov. Ferric sucrose tov tov yog tshuaj tsuag ziab kom tau txais lub xeev.

kev npaj

Txoj Kev 2:

1. Cov muaju: Kho tus nqi sam ntawm cov tshuaj raws nraim li 1 ~ 3 nrog rau cov roj ntsha ua kom sib xyaw kom haum rau 4 ~ 7, lim. Ntxiv dej kom tau txais kev daws teeb meem;
2. Kev sib xyaw: cua sov txoj kev daws teeb meem, ntxiv cov lus dag, ntxiv cov tshuaj discus, cov sawv ntsug tseem thaum hmo ntuj kom tau txais kev daws teeb meem;
3. Refining: cov kua nyuaj tom qab tas hmo ntuj yog lim, cov filtrate yog precipitated nrog 2 mus rau 3 zaug ethanol, thiab lim, yog, hlau sucrose.

Cov Ntaub Ntawv Kev Nyab Xeeb

Code Code: 29400090

Toxicity: LD50 in mice (mg Fe/kg): >2500 orally; >200 iv (geisser)

Cim npe nrov: Hlau Sucrose Ntxiv, Tuam Tshoj Hlau Sucrose Cov Khoom Siv Khoom Siv