Rocuronium bromide txha pob txha pob txha cov leeg kom txaus

English Lub Npe: Rocuronium Bromide

Tus lej lej: 119302-91-9

Molecular cov mis: c32h53bn2o4

Molecular hnyav: 609.68

Einecs tus naj npawb: 601-597-6

Lwm Qeb

Cov raub ntov; Cov tshuaj narcotic; Tshuaj; Tshuaj thiab biochemistry; Cov ntaub ntawv raw; Cov me me molecule inhibitor; Cov ntaub ntawv rawcuitical; Lwm yam khoom siv science; Lub cim xeeb; Cov reagent biochemical; Intermediates & zoo tshuaj lom neeg; Acetylcholine receptor; Hetercycles; Steroid; Cov Ntawv Chog Tshuaj Steroid thiab Hormone; Isomer impurities; Tshuaj Nruab Nrab Hluav Taws Xob; 1; Cov khoom siv raw; Tshuaj Kev Lag Luam; Cov ntaub ntawv rawcuitical; Cov khoom xyaw; Kws muag tshuaj, tshuaj tua kab thiab zas xim nruab nrab; Cov Khoom Siv Raw Tshuaj; Cov khoom siv cov khoom; Tshuaj lom neeg cov tshuaj lom neeg; Cov kab mob tsis sib haum xeeb; Cov tshuaj hauv tsev; Lwm tus; Cov khoom tswj; Kws muag tshuaj; APIS; 119302-91-9; API

Mol Cov Ntaub Ntawv: 119302-91-9. Mol

Cov Qauv Txheej Txheem:

Cov khoom ntawm Rocuronium bromide

Melting taw tes: 162-1640 c

Kev sib hloov tshwj xeeb: D 20+18. 7 Qib (C {2}}. 03inCl3)

Cov xwm txheej: Inertatmosphere, 2-8 degree

Solubility: ipubbility ntawm 100mg / ml hauv dej, ntshiab, lub teeb daj

Daim Ntawv: Khoom

Xim: dawb rau daj

Dej Solubility: H2O: 100 mg / ml, qhov tseeb, cov nyom

Merck: 14,8246

Stability: hygroscopicity

Inchikey: Oytjkrayyrujk-FMCCZJBLSA-M

CAS database: 119302-91-9 (CASTE)

Tsis-depolarizing cov leeg rauble

Rocuronium bromide, pancuronium bromide, vecuronium bromide, atrolicizium thiab pipecurizium yog ntau cov leeg nqaij religanes siv nyob rau hauv chaw kuaj mob hauv Suav teb tam sim no. Rocuronium muaj cov nyhuv ceev tshaj plaws thiab tuaj yeem muab cov leeg ua kom zoo tshaj plaws uas nyob hauv 60 ~ 90s. Tsis yog-depolarizing kev siv mis mis tsis hloov lub cev muaj peev xwm ntawm lub cev muaj zog tas nrho Ua ntej qhov pib ntawm cov leeg kom txaus, chav ua haujlwm no tsis yog tsim cov leeg los ntawm cov pob txha pob txha pob txha, raws li muaj cov leeg depolarizing.

Rocuronium bromide yog qhov kev ua yeeb yam ntawm vecuronium bromide thiab muaj tib cov nyhuv, tab sis tsuas yog 1/7 ntawm nws lub zog. Cov nyhuv tau nrawm tom qab kev txhaj tshuaj ntxiv, cov interubation tuaj yeem ua hauv 6 {}} {8}}} ntev ntev li 30 txog 40 feeb. Nws tsis muaj qhov pom tseeb ntawm autonomic hlab thiab coligiovascular, tab sis tuaj yeem txo cov kev xav tau zoo, tsis muaj histramine tso tawm thiab kev khuv xim ganglion thaiv cov nyhuv. Nws yog feem ntau siv rau endotracheal intubation hauv chaw kho mob, thiab tseem siv tau rau kev saib xyuas ntawm cov leeg nqaij kom txaus hauv ntau yam kev phais mob. Interberation tau ua nrog ib qho kev txhaj tshuaj ntawm 0.6mg / kg thiab ib lub tshuaj saib ntawm 0.15mg / kg. Cov khoom no tuaj yeem hla kev fab tshuaj nrog rau lwm cov leeg cov leeg, yuav tsum tau siv nrog kev ceev faj. Mob siab thiab lub raum tsis txaus, cov neeg laus nrog ceev faj.

Cov ntaub ntawv saum toj no tau muab tso ua ke los ntawm cov tshuaj lom neeg

Pharmacological txiav txim siab

Cov kev sib tshuam neuromuscular suav nrog kev ntsuas lub cev muaj zog thiab lub cev muaj zog. Nyob rau hauv lub cev muaj mob, thaum cov hlab ntsha immulse yog kis mus rau lub cev muaj zog nkag nrog lub cev muaj zog fuse nrog lub suab paj nruag qhov kawg, thiab cov tshuaj acetylcholine, thiab acetylcholine nyob rau hauv hlwv. Tom qab acetylcholine tawm cov leeg cov tshuaj pleev ib ce, cov tshuaj lom neeg nrog cov ion channel qhib thiab cov sodium ion ntws sab hauv, ua rau muaj cov leeg nqaij ntawm cov leeg nqaij. Cov leeg ua rau cov leeg ua haujlwm. Cov raugle tuaj yeem muab faib ua cov nplaig thiab cov leeg tsis sib xws raws li lawv txoj kev cuam tshuam nrog cov hlab ntsha tsis sib haum ntawm cov chaw neuromuscular.

Rocuronium bromide yog qhov tsis muaj-depolarizing neuromuscular blocker nrog cov qauv tshuaj lom neeg zoo ib yam li vecuronium thiab pancuronium. Zoo li lwm cov tshuaj tsis yog-depolarizing, nws kev sib tw khi rau choline recapsors ntawm cov khoom siv lub cev muaj zog los thaiv cov teebmeem ntawm acetylcholine. Qhov kev txiav txim ntawm cov tshuaj tau nrawm, tab sis qeeb dua li ntawm succincholine, thiab kev nyab xeeb yog ntev, lub sijhawm ua tau ntev, thiab muaj kev cia siab. Ntawm cov tsis-depolarizing neuromuscular blockers, Rocuronium muaj lub sijhawm nrawm nrawm, muab cov xwm txheej ua tau zoo rau kev txhaj tshuaj ntxiv tom qab 60s ntawm kev txhaj tshuaj tiv thaiv tom qab 60s ntawm kev txhaj tshuaj tiv thaiv zoo. Txawm hais tias lub sijhawm pib tsis ntev dua li ntawd ntawm kev coj noj tshuaj choline, nws yog ob zaug nrawm li vecuronium thiab carcinine. Yog li ntawd, Rocuronium bromide tuaj yeem hloov pauv rau succincholine thaum lub sijhawm ua haujlwm nrawm dua qub interubation. Txawm li cas los xij, succininoline muaj sijhawm luv luv (feem ntau tsawg dua 10min), thaum cov khoom no kav ntev li 30min, zoo ib yam li Vecuronium thiab Carrinine nyob rau hauv lub laj thawj no. Piv nrog rau lwm cov leeg rauble, Rocuronium muaj cov txiaj ntsig kev nyab xeeb rau lub cev muaj zog dua cov cancolura chloride thiab pancuronium, tab sis yog zoo ib yam li vecuronium. Kev ua kom loog sab nrauv tsis cuam tshuam rau cov nyhuv neuromuscular thaiv cov nyhuv ntawm cov khoom no, tsis yog nws tsis cuam tshuam rau cov txheej txheem kev ua.

Ib nrab koob tshuaj tau zoo (ed5 0}}}}% siv tau zoo rau cov menyuam yaus yog 17}}}}} thiab 303ug / kg, feem. Tom qab txhaj tshuaj ntawm 600ug / kg, lub sijhawm pib ntawm 90% thiab 100% neuromuscular blockade yog 0.8 thiab 1.3min, ntsig txog. Lub sijhawm xav tau rau 25% rov qab los ntawm neuromuscular conduction yog 27min. Hauv cov neeg laus neeg mob (ntau tshaj 70 xyoo), lub sijhawm ntawd zoo ib yam li cov tub ntxhais hluas, tab sis lub sijhawm tshem tawm ntawm cov ntshav huv, thiab cov ntim ntawm kev faib tawm raug txo. Nyob rau hauv lub raum hloov cov neeg mob uas xa tawm, muab tshem tawm ib nrab hnub, tab sis lub sijhawm ntawm cov neeg tsis paub tab Tom qab txhaj tshuaj ntawm 0.6mg / kg, lub sijhawm pib ntawm neuromuscular blockade hauv cov neeg mob ib txwm muaj sia nyob rau hauv lub neej (158min ± ntev dua li 97min ± 37min ± 37min ± 16min, feem.

Pharmaconinetics

Tom qab txhaj tshuaj tiv thaiv ntshav, cov theem kev sib raug zoo-lub sij hawm sib txuam nrog ib nrab-lub neej ntawm 203 ({}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}) ml / kg. Kev tshuaj tsw qab ntshav yog 3.9 (± 1.3) ml / KG / min. Kev tshawb fawb tswj hwm tau pom tias tau pom cov ntshav huv thiab cov neeg mob siab lossis cov kev tshawb fawb tsis txaus, tab sis feem ntau cov kev tshawb fawb tsis muaj kev hloov pauv. Kev tshem tawm ib nrab-lub neej ntawm cov neeg mob nrog kab mob siab tau txuas mus rau qhov nruab nrab ntawm 30 feeb. Txoj kev tshem tawm tseem ceeb ntawm cov khoom no yog biliary tso kua. Hauv ob peb teev, 30% rau 40% ntawm cov koob tshuaj yog tawm los ntawm cov kua tsib hauv nws daim ntawv qub.

Kev taw tes

Rocuronium yog siv los ua ib qho kev txiav txim siab rau cov tshuaj loog dav dav rau endotracheal intubation thaum niaj hnub ua kom cov leeg ua kom tsaug zog thaum phais mob.

Kev Ntsuam Xyuas Kev Kho Mob

Hauv cov neeg mob loog, Rocuronium yog 6 txog 8 zaug tsis muaj zog nyob rau hauv cov leeg so ntau dua li vecuronium thiab atracuronium, tab sis cov nyhuv ceev dua. Feem ntau tom qab txhaj tshuaj ntawm {2}}. 5 ~}}, thiab lub sijhawm ua tau zoo ib yam li ntawm Vecuronium bromide thiab atracuronium. Piv nrog suprcinylcholdcholine, cov nyhuv ntawm cov khoom no tau nrawm dua, thiab chaw kuaj mob hauv lub sijhawm tseem tseem muaj lub sijhawm ntev ntev.

Cov teeb meem xav tau mloog

Cov khoom no tuaj yeem ua pa tawm dag zog, thiab cov neeg mob yuav tsum siv cov pa ua pa ua pa ua pa kom txog thaum muaj ua pa. Vim tias cov khoom no ib txwm siv ua ke nrog lwm cov tshuaj, malignant hyperthermia yuav tshwm sim txawm tias tsis paub txog cov tshuaj thaum lub loog. Yog li ntawd, cov kws khomob yuav tsum paub txog nws cov cim ntxov, ua rau muaj kev mob meej thiab muaj peev xwm kho tau malignant hyperthermia ua ntej muaj tshuaj loog. Cov neeg tshawb nrhiav tsiaj tau pom tias Rocuronium bromide tsis yog ib qho kev kub ntxhov ntawm malignant hyperthermia.

Cov cuab yeej tshuaj

Crystallization, melting point 161 ~ 169 degree. [] D 20+18. 7 Qib (C =1. 03, chloroform).

Kev siv

Cov raub kom txav. Tsis-depolarizing neuromuscular blockers. Siv los ua tus vaj ntxwv thaum lub sijhawm tshuaj loog dav dav thiab cov leeg ua pob txha tsis muaj zog, nws tuaj yeem so cov leeg thiab phais cua.

Mob pob txha relaxes (tsis-depollizing)

Cov raub kom txav. Tsis-depolarizing neuromuscular blockers. Siv ua ib qho kev sib tw ua kom tiav Mazui thiab cov niaj hnub tracheal inpatient inpatients hauv kev mob pob txha thaum phais thiab cua tshuab cua.

Txuj Ci Ntau Lawm

(2, 3, 5, 17, 17) {{5} {} {{{{{{{{{{{{{{{{{{{{} {{ methanol thiab txo qis rau compound (ⅲ). Thiab Morphine aqueous daws tau reflow rau 3D kom tau txais compound (ⅳ). Qee yam acetylated thiab tom qab ntawd reacted nrog allyl bromide los tsim cov khoom.

Cov Ntaub Ntawv Kev Nyab Xeeb

WGK Lub Tebchaws Yelemees: 3

Code Code: 2934990002

Cim npe nrov: Rocuronium bromide txha pob txha ruantant, Tuam Tshoj Rocuronium bromide pob txha pob txha taub hau