Tirzepatide HypoglyCemic Tshuaj

Lus Askiv Lub Npe: Tirzepatide
Tus lej lej: 2023788-19-2
Molecular cov mis: c225h348n48o68
Molecular hnyav: 4813
Einecs tus naj npawb: 200-001-8

Lwm Qeb
Polypepride; Cov me me molecule inhibitor; Catalog peptide; Polypepride; Tshuaj polypeptide; Kev zoo nkauj polypepride; Peptide tshuaj; Cov ntaub ntawv rawcuitical; Lwm tus; Cov khoom tshiab; APIS; API; Belka staple
Mol Cov Ntaub Ntawv: 2023788-19-2. Mol
 

Cov Qauv Txheej Txheem:

Cov khoom ntawm tilpotide

Cia: Khw ntawm -20 degree

Solubility: yaj nyob hauv dimethyl sulfoxide

Daim Ntawv: Khoom

Xim: Dawb rau beige

Sequence: Tyr- {Aib {-gllu-Gly-Ser-Tyr-Tyr-Tyr-Tyr-As-Lile-Gra-GLA-{{{} g Amma-Glu- (AEea) {23} Lys} Lys}-Gly-Gly-Gly-A-Gly-Ala-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Pro-Ser-Ser-Ser-Ser

HypogyCemic tshuaj

Tirzepatide (Tirzepatide) yog cov tshiab geptide-{}}}}}}}}} Cov pa roj av (GLP}) Ob lub GLP -1 thiab gip yog rau incretin, uas yog polypeptide zais cia los ntawm cov plab zom mov. Lub qub tuaj yeem khi rau cov receptors ntawm islet ntawm islet ntawm aitecemic cuam tshuam thiab inhibiting patric nchuav thiab inhibiting ce, yog li tswj lub cev hnyav. Cov tom kawg muaj cov kev ua haujlwm ntawm cov pa roj plab, pepsin zais pa, ua rau muaj cov txiaj ntsig ntawm Insulic, uas tuaj yeem ntxiv rau cov nyhuv insulin, thiab tuaj yeem ntxiv rau cov nyhuv insulin, thiab tuaj yeem ntxiv cov nyhuv ntawm GLP {7}} Tam sim no Receptor Egonist. Tirzepatide muab cov kev tshwm sim ntawm ob insulin-txhawb cov tshuaj mus rau ib chav ntawm cov tshuaj tshiab rau kev kho cov tshuaj mob ntshav qab zib hom 2.

Cov molecule muaj cov pob txha peptees ntawm 39 amino acids thiab ib sab saw ntawm Lys3. Ntawm 39 amino acids, 37 yog ib txwm muaj tshwm sim (lossis ob qho tsis muaj txiaj ntsig, tsis yog-ploj amino iSobutyric acid seem ntawm txoj haujlwm 2 thiab 13.

Kev siv

Tirzepatide muaj ib qho zoo sib xws Lub ntsiab muaj sia ntawm tirzepchemicalBookatide yog cov piam thaj ua noj muaj txiaj ntsig polypeptide (gip) thiab glucagon} (Glucagon} (Glucagon}

Kev tsis muaj teeb meem

Cov kev nyab xeeb profile ntawm Tilpotide yog zoo li ntawm lwm cov tshuaj incretin. Kev txheeb xyuas meta-tsom xam cov kev sim ua kom muaj zog uas tau pom tias Telpotide (xws li mob plab zom mov (mob plab zom mov) dua li! Lwm cov tshuaj tiv thaiv uas tsis zoo, tshwj xeeb yog hypoglycemia, tau tsis txawv ntawm ob pawg. Txawm li cas los xij, vim lub sijhawm luv luv, kev nyab xeeb tiag tiag tseem yuav tau tso tawm tom qab cov npe.

Kev cuam tshuam loj% thiab poob phaus

Kev Tshawb Fawb Laus yog cov chaw kuaj mob loj tau tsim los ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawm kev sib tw thiab kev nyab xeeb hauv cov neeg mob hom 2 Ntshav Qab Zib Mellitus (T2Dm). Lub taub hau rau lub taub hau sib piv nrog semaglutide surpass 2 [}} mg (n {}}}} Telpotide txo HBA1C los ntawm qhov nruab nrab ntawm 2.0%, 2.2% piv nrog cov hauv paus HBA1C (THAUM SEMAGLUTIDE txo HBA1C los ntawm qhov nruab nrab ntawm 1.9%. Nyob rau hauv cov nqe lus ntawm kev poob phaus, telpotide ua rau muaj qhov hnyav nruab nrab ntawm 17, 21, thiab 25 phaus piv rau cov hauv paus hnyav (207 phaus), piv nrog 13 phaus rau semaglutide. Qhov kev sim tsom qhia tias Tilpotide qhia tau zoo dua hypoglycemic thiab lub peev xwm poob phaus dua li semaglutide.

Lwm qhov kev tshawb no loj cuv npe kawm 2,539 tus neeg laus muaj tsawg kawg ib txoj kev rog rog (BMI) ntawm ntau dua lossis muaj ntau dua lossis sib luag rau 27kg / m2. Txhua yam kev kawm tau muab faib ua ke rau hauv tongotide cov tshuaj xom. Cov txiaj ntsig tau pom tias lub cev nyhav ntawm txhua pawg poob los ntawm 16.1kg, 23.6k, ntsig txog 2.42 lub lis piam [2]. Lub cev yuag yuag ntawm tilpotide yog sib piv rau qhov kev phais poob phaus.

Polypeide

Tilpotide muaj qhov zoo sib xws rau semaglutide. Lub Lys sab saw hauv cov ntu muaj PEG hloov kho, uas yog cov pab pawg polypeptide thiab tuaj yeem nce cov dej solubility ntawm kev sib cais. Telpotide lub ntsiab lus tseem ceeb yog cov dej qab zib roj polypeptide (gip) thiab glucagon}

Kev siv cov qauv zoo

Zog: Cov hmoov dawb dawb

Purity (hplc): ntau dua lossis sib npaug rau 95. 0%

Acetic acid cov ntsiab lus: 5. {{}}}% ~ 12. {{%

Cov ntsiab lus noo: tsawg dua los yog sib npaug rau 8. 0%

Cov ntsiab lus peptide: ntau dua lossis sib npaug rau 7 0. 0%

Amino acid muaj kev txheeb xyuas: tsawg dua los yog sib npaug ± 10%

Cim npe nrov: Tirzepatide hypoglycemic siv yeeb tshuaj, Tuam Tshoj Tirzepatide HypoglyCemic Cov Chaw Siv Tshuaj