Panitumumab Monoclonal Antibody rau Cancer

Lus Askiv Lub Npe: Panitumumab

Tus lej lej: 339177-26-3

Molecular Cov Qauv

Molecular hnyav: 0

Einecs tsis muaj

Lwm yam ntawm cov tshuaj

Reagent Mol: File Mol cov ntaub ntawv

Cov Qauv Txheej Txheem

Cov Khoom Siv Panitumabab

Kev Cia Cov Neeg Tiv Thaiv: Khw ntawm -20 c

Daim Ntawv: Ua Kua

Xim: tsis muaj xim daj rau daj daj

Lub ntsiab

Panitumumab yog thawj humanonal monoclonal antibody tsom rau cov Epidermal kev loj hlob Factor tus neeg txais (EGFR). Piv txwv li feem ntau pab tswj txoj kev loj hlob hauv tib neeg, tab sis nws kuj ua rau kev loj hlob ntawm kev loj hlob ntawm cov qog nqaij hlav cancer cances. Piv txwv li EgFr yog nyob rau ntawm sab ntawm cov qog nqaij hlav cancer, thiab thaum cov protein txuam nrog orgfr, piv txwv li Epidermal kev loj hlob ib (TGF-Alpha). Kev sib xyaw ua ke hloov cov morphology ntawm EGPR thiab txhawb kev qog ntshav loj hlob. Panitumumab nrog EGFR tiv thaiv nws txoj hlua khi rau EGF lossis TGF-Alpha, yog li thaiv Cancer Cancer kev loj hlob.

Soj ntsuam daim ntawv thov

Banitumab yog Metastatic tshuaj lom neeg cancer nrog EGFECTIONS EGF kev qhia thiab kev pib ua tom qab fluorouracil, oxaliplatin thiab irinotecan. Rau Metastatic Colorical Cancer nrog kev loj hlob ntawm Epidermal Epeptor Feltor Fluor (EGFR) qhia fluorouracil, oxaliplatin, thiab iRinoTecan.

Ua ke nrog fluorouracil, leucovorin, thiab oxaliplatin (FOR Oxaliplatin (Folfox4 Regimen) raws li thawj-kab kev mob qog nrog cov tsiaj qus-hom Kras qus.

Ua ke nrog fluorouracil, leucovorin, thiab Irineotecan (Folreotecan (FolreCi Regimen rau Metastatic Colorument Kras tom qab fluorouracil-muaj cov tshuaj lom neeg.

Bioactivity

Panitumumababababer (Panitumumab) yog ib lub IGG 2 monoclonal antibody muaj kev sib raug zoo rau piv txwv li eGFr. Panitumumab (Panitumumab) tau tsim siv Abgenix lub Xenomous Technology raws li kev tshuaj pleev mandenody monoclonal tsis muaj protein ntau. Lub cev tsis muaj zog tuaj yeem lees paub txog cov tshuaj tiv thaiv nas hauv cov tub rog siv hluav taws xob, xws li ua rau cov lus teb tsis muaj zog, xws li Txoj Kev Cuam Tshuam, kev ua xua. Thiab tag nrho tib neeg monoclonal tshuaj tiv thaiv tuaj yeem txo cov lus teb tsis muaj zog thaum muab kev kho mob zoo.

Cov chaw soj ntsuam

Kev vam khom-dawb ciaj sia taus thiab tag nrho cov ciaj sia nyob tau ntev ntev nyob rau hauv lub panitumumab (Panitumumum) -Tus pab pawg. Piv nrog rau cov kws kho mob ntxiv rau avastin regimen, ntxiv rau ntawm cov tshuaj lom neeg cov tshuaj lom neeg ua tsis tau tejyam ua tsis tiav ntawm kev sim siab. Txawm li cas los xij, cov neeg mob randomized rau cov pab pawg ua haujlwm rau kev kho mob

Untoward nyhuv

1. Pulmonary fibrosis yog qhov kev cuam tshuam loj tshaj plaws ntawm cov pa roj av. Thaum lub sij hawm noj tshuaj, lub cev muaj zog yuav tsum tau saib xyuas tsis tu ncua thiab xoo hluav taws xob yuav tsum tau ua. Ib zaug pulmonary fibrosis tshwm sim, cov tshuaj yuav tsum nres tam sim ntawd.
2. Yog tias cov kab yoov tshwm sim li 30 feeb tom qab noj tshuaj, dexamethasone 5 mg tuaj yeem tswj hwm tau zoo.
3. Sib sib zog nqus cov ntaub thaiv npog venous thiab thrombophbitis tau pom hauv cov hlab plawv.
4. Kev mob siab hnoos (9% rau 14%), dyspnea, thiab pulmonary fibrosis (<1%).
5. Cov chevastroşeaTagestion (2% mus rau 7%), ntuav (25%, mob me ntsis (4%)), raws plab (21% mus rau 58%), Tsis-kis lub plab zom mov mucosal o (6%).

Cov Ntaub Ntawv Seev Cev

Cov ntaub ntawv MSDS

Cim npe nrov: Panitumumab Monoclonal tshuaj tiv thaiv rau mob cancer, Tuam Tshoj Panitumumab Monoclonal Antibodody rau cov neeg xa cov qog