Bevacizumab Monoclonal Antibody

ENISCE npe: Bevacizumab Monoclonal Antibody

Tus lej lej: 216974-75-3

molecular cov mis: C6638H10160N1720o210S44

Einecs tus naj npawb: 200-160-3

Related: Cov Khoom Siv Tshuaj; Mab 5; tshuaj yeeb tshuaj thiab cov nruab nrab; Tshuaj Nplaum Xov Xwm

Cov Qauv Txheej Txheem:

Morphological: Kua

Xim: tsis muaj xim rau lub teeb daj

Zauv ntawm cia: Khw ntawm -80 degree

Solubility: yaj nyob hauv dimethyl sulfoxide

Lub ntsiab

Avastin, tsim los ntawm Roche thiab pom zoo los ntawm Asmeskas Cov Khoom Noj thiab Tshuaj Siv Tshuaj (FDA) hauv xyoo 2004, tam sim no thawj cov tshuaj tiv thaiv cov tshuaj tsw qab. Los ntawm inhibiting vascular endothelial kev loj hlob ntawm kev loj hlob (vummen Nws tuaj yeem siv nyob rau hauv feem ntau cov qog thiab ntau dua siv rau kev kho mob ntawm metastatic Colorical Cancer thiab Mob ntsws Cancer.

Pharmacological txiav txim siab

Ua tshuaj tiv thaiv vcifation volifation, nws yog ib lub igg 1 monoclonal attibody suplection

Mechanism ntawm Kev Ua

Bevacizumab ua tiav kev tiv thaiv kev tiv thaiv kev cuam tshuam los ntawm cov qog ntshav angiogenesis, thiab cov tshuaj khib nyiab, thiab cov tshuaj lom neeg tsim cov qog qog cond pa. Ntxiv mus, Bevacizumab muaj tseeb heev, thiab thaiv ib qho GF txoj hauv kev feem ntau tsis cuam tshuam nrog lwm lub hom phiaj.

Ua ntaub ntawv

1.Txhua kev kho mob ntawm cov qog, xws li hauv kev kho ntawm psoriasis.

2.Ors thawj-kab kev kho mob ntawm cov neeg mob uas muaj mob qog noj ntshav zoo

3.Rau cancer thiab kuj tseem siv tau rau kev mob qog noj mis thiab mob ntsws. Txheej txheem cej luam, cov khoom siv hluav taws xob, cov khoom pom, cov nyom, thiab lwm yam.

Untoward nyhuv

Cov kev nyuaj siab loj tshaj plaws yog cov ntshav tawm tsam, kev tawm tsam, kev nyuaj siab, Neb suav tsis tau, thiab lub siab tsis ua hauj lwm. Cov kev tawm tsam loj tshaj plaws tsis muaj zog, kev mob siab, kev kub siab, raws plab, thiab tshuaj lom neeg cell. The most common adverse reactions are: weakness, pain, abdominal pain, headache, high blood pressure, diarrhea, nausea, vomiting, decreased appetite, stomatitis, constipation, upper respiratory tract infection, epistaxis, dyspnea, exfoliative dermatitis, and proteinuria.

bioactivity

Bevacizumab (anti-ve gf, avastin) yog ib tug neeg los tiv thaiv gf monoclonal antibodody, lwm cov tshuaj lom neeg, uas yog ib qho inhibitor ntawm v gf. Tuaj yeem khi thiab nruab nrab nrog tib neeg - tau los ntawm cov gf-a isoforms (thiab biologically actionic tawg) .mw: 149kd.

Phiaj Xwm

Lub Hom Phiaj

Vegfr2

()

Vegf-a

()

Tus vegf

()

Hauv kev kawm vitro

Gly 88 ntawm tib neeg ve gf yog qhov tseem ceeb rau Bevacizumab khi thiab suav tias yog cov khoom siv acid acid Cov neeg hauv tsev neeg, xws li vef-b lossis gf-c.

Hauv Vivo Tshawb Fawb

Hauv tib neeg, lub davhlau ya nyob twg ib nrab-lub neej ntawm Bevacizumab yog 17 - 21 hnub. Hauv cov nas liab qab, Bevacizumer Inhibited txoj kev loj hlob ntawm tib neeg cov qog ntawm cov tshuaj {} mg / kg (ob zaug ib lim tiam). Cov koob tshuaj yuav tsum muaj rau ib nrab-maximal inhibition yog 0. {}}. 5mg / kg. Kev ntsuas kev nyab xeeb ntawm Bevacizumab hauv Macacafascusis (CynomolgusMon), nrog kev nce qib bondrophic, cov neeg hluas: Cov Hluas Kev Ntxim Nyoog, Inhibition of Vascular ntxeem tau hauv thaj chaw loj hlob. Cov thawj coj ntawm lub sijhawm ntev bevacizumab inhibited vascular kev loj hlob hauv cov poj niam system, poob phaus nyob rau lub zes qe menyuam thiab lub tsev menyuam, thiab poob ntawm lub sam thiaj li. Cov kev hloov pauv ntawm cov phiaj xwm kev loj hlob thiab ovary tau thim rov qab thiab tuaj yeem rov qab tau maj mam tom qab kev txiav tawm ntawm kev kho mob. Ntxiv mus, tsis muaj lwm cov kev pab cuam sab-cuam tshuam muaj tshwm sim tau pom ntawm cov tshuaj muaj ntau txog 50mg / kg. Tom qab kev txhaj tshuaj ntxiv, cov xyoob xyoob ntawm RhumabveGF (Bevacizumab) yog 69% hauv nas, piv nrog 100% hauv nas thiab cynomolgus liab. BevaBacizumab khi rau kev ua tsaug rau gf thiab rau luav ve gf nrog tsawg aominity, tab sis tsis yog kom nas thiab nas ve gf.

Cov Ntaub Ntawv Seev Cev

Cov ntaub ntawv lom neeg cov ntaub ntawv: {216974-75-3 (cov ntaub ntawv muaj kev phom sij)

Cim npe nrov: Bevacizumab Monoclonal Antibody, Tuam Tshoj Bevacizumab Monoclonal Antibody