Rituximab Cooks Cov Kab Mob autoimmune thiab Cancer

Lus Askiv Lub Npe: Rituximab
Tus lej lej: 174722-31-7
Molecular Cov Qauv: C6416H9874N4688o1987S44
Molecular hnyav: 0
Einecs tsis muaj.:
Lwm yam pawg: Cov tshuaj tiv thaiv biochemical-protein; tshuaj yeeb tshuaj; Mab 18; tshuaj yeeb tshuaj thiab cov nruab nrab; Tshuaj Tshuab
Cov Mol Cov Ntaub Ntawv: MOL cov ntaub ntawv
Cov Qauv Txheej Txheem:

Xwm ntawm Rituximabstorage
Cov Zej Zog: Khw ntawm -80 c
Daim Ntawv: Ua Kua
Xim: tsis muaj xim daj rau daj daj
 

Cov lus qhia luv luv

Rituximab antigen Tshawb Fawb Npe (Mabthera), yog tsim los ntawm CD20 Monbonal Antibody (los ntawm Nees Dag "Culprit"). Tam sim no, muaj twb muaj cov yeeb tshuaj muaj nyob hauv Rituximab hauv Suav teb.

Pharmacological cuam tshuam thiab lawv cov teebmeem

Mechanism ritximab yog ib qho tshwj xeeb tiv thaiv B Cell Chereric, thiab tsuas yog qhia txog cov tshuaj lom neeg, thiab tsuas yog qhia txog cov tshuaj lom neeg ntawm cov tshuaj lom neeg los tsim cov thaiv cov tshuaj tiv thaiv kab mob. Vim tias CD20 tsis tshwm sim hauv Hematopoietic qia hlwb thiab lwm cov ntaub so ntswg, Rituximab tuaj yeem ua kom muaj kev tiv thaiv kev nyab xeeb thiab muaj kev nyab xeeb profile. Nws tau pom zoo tau pom zoo los ntawm Asmeskas Cov Khoom Noj thiab Tshuaj rau kev kho mob tsis-hodgkin lub lymphoma.

Kev taw tes

1. Tsis-Hodgkin's Lymphoma (NHL).
2. Ntev Lymphocytic nyukemia (CLL).
3. Rheumatoid mob caj dab (RA): Cov neeg mob laus uas muaj mob hnyav rau tus neeg uas teb tsis tau nrog ib lossis ntau dua tnf antagonists.
4. WeGener Granuloma (WG) thiab microscopic polyvasculitis (MPA) tau ua ke nrog Glucocorticoids hauv cov neeg mob laus.

Untoward nyhuv

1) Lymphoid Malignant tus kab mob: Cov kev sim siab nquag hauv NHL cov kev sim siab yog: kev ua txhaum, kub ntxhov, ua rau muaj mob, ua rau muaj mob Cov kev tsis zoo tshwm sim hauv CLL chaw sim tshuaj ntsuam yog: Txoj kev sib cav sib txujcus uas yog Neutropenia.

2) Rheumatoid mob caj dab (RA): Cov kev cuam tshuam tshwm sim hauv kev sim tshuaj tiv thaiv kab mob: Kev mob ua pa sab saud, mob plab zom zaws, mob plab zom mob, mob ntsws. Lwm cov txiaj ntsig tseem ceeb suav nrog In Insisferactions, kis mob hnyav, thiab cov xwm txheej plawv.

3) Cov khoom siv granuloma (wg) thiab microscopulitis (MPA): Kev tsis zoo, mob plab zom mov, mob plab zom mov, mob plab, ntshav, anemheral edema. Cov kev sib raug zoo uas tseem ceeb suav nrog cov kev lis ntshav cuam tshuam.

Bioactivity

Rituximab (anti-cd20) yog tus mob siab tawv los tiv thaiv cd20 antigen ntawm C cd20 antigen on CYDING AFFINE ntawm 5 NM.M.M. {} kd.

Phiaj Xwm

Lub Hom Phiaj

Cd20

Hauv kev kawm vitro

Lub potency ntawm rituximab nyob ntawm nws cov lus tau ua tiav (CDC), kev tiv thaiv Cytotoxicity (Adcc) thiab Apoptosis induction. Rituximab tuaj yeem ntxias kom tuag ntawm Malignant B cell hauv vitro. Lub zog ntawm kev ua tau zoo sib txawv nrog cov sib txawv ntawm cov hlwb. Nyob rau hauv vitro, chiecbookrituximab-ua rau cov kev hloov cellular) yog: p38mapk, nf- κ b, Ent anti-apoptotic, inhibition rau kev ciaj sia ntawm txoj kev taug. Rituximab ua tau zoo rau kev kho kom zoo rau kev sib kho cov kev sib txawv (cmc) ntawm sib txawv b cell kab thiab malignant B cell. Lub cd 20-} Cov peev xwm ntawm Rituximab yog qhov kev xav tau.

Hauv Vivo Tshawb Fawb

Qee tus hauv Vivo cov qauv qog tau pom tias yuav ua tus kabmob antitumt ntawm rituximab nyob ntawm ua ke ntawm kev ua tiav (tsawg kawg hauv ib feem). Rituximab tuaj yeem rho tawm B Cell thiab mob siab rau cov tshuaj siv tau los ua cov tshuaj kho tau zoo rau kev kho mob ntawm tes-kho kab mob autoimmune. Nyob rau hauv kev kho mob ntawm hematological hlav, rituximab tau siv dav siv thiab tam sim no muaj kev tsim kev tshuaj rau kev kho mob autoSommune kab mob.

Cov Ntaub Ntawv Seev Cev

Cov ntaub ntawv muaj tshuaj lom: 174722-31-7 (cov khoom muaj kev phom sij)

Cim npe nrov: Rituximab Cares cov kab mob autoimmune thiab mob cancer, Tuam Tshoj Rituximab Medica thiab cov neeg siv tshuaj khum autimmune autoimmune