Amphouricini B Polyene Antifungal tshuaj

English Lub Npe: AMPHOTICICEYIN B

Tus lej lej: 1397-89-3

Solubilized; amphotericin b, soluble

Molecular cov mis: c47h73no17

Molecular hnyav: 924.08

Einecs tus naj npawb: 215-742-2

Lwm Qeb

Cov khoom siv raw; Microbial metabolites; Reagent rau kev tshawb fawb; Cov khoom lag luam siv, cov khoom lag luam; Cov reagent biochemical; Enzymes; Tshuaj tua kab mob, alkaloids; Genomics thiab molecular kev kuaj; Ntau yam tshuaj lom neeg cov tshuaj tiv thaiv; Cov me me molecule inhibitor; Tshuaj tua kab mob; Me me molecule inhibitors, khoom siv ntuj; Tshuaj tua kab mob; Cov khoom siv raw; Cov khoom siv qub siv. Kws Tshuaj Kho Mob thiab Kev Lag Luam; Tshuaj lom neeg cov tshuaj lom neeg; API; Cov ntaub ntawv rawcuitical; Cov khoom xyaw; Cov hluavtaws tshuaj tiv thaiv hluav taws xob; Tshuaj lom neeg cov tshuaj lom neeg; Cov ntaub ntawv rawcuitical; Cov Khoom Siv Raw Tshuaj; Tshuaj lom neeg cov tshuaj tiv thaiv - Tshawb nrhiav kev tawm tsam; Cov ntaub ntawv rawcuitical; Zoo tshuaj lom neeg cov ntaub ntawv; Reagent; General biochemical reagents - tshuaj tua kab mob; Tsiaj cov ntaub ntawv raw; Lwm yam tshuaj tua kab mob; cov tshuaj tua kab mob; mLS; cov tshuaj tua kab; cov tshuaj tiv thaiv kab mob; cheekem iCalbookStrucassencass; cuam tshuam nrog rau cov tshuaj tua kab mob (ionophores) tshuaj tua kab mob; tshuab; reagenta ndsupplemation; Spectrumofactivation; antifungal; carbohydrates & derivative; chiralcet; awitors; ecis; 1397-89-3; Kev reagent biologent; Khoom Siv Khoom

Mol Cov Ntaub Ntawv: 1397-89-3. Mol

Cov Qauv Txheej Txheem:

Cov Khoom Ntawm Amphotericin B

Melting point: >170 Qib

Kev sib hloov tshwj xeeb: D {{0}}} degree (acidicdmf); 33.6 Degree NMethanolichClicCl (0.1)

Boiling taw tes: 804.34 degree (ntxhib)

Saib ceev: 1.34

Refuntion Prex: 1.5280 (kwv yees)

Kev Cia Mob Cia: 2-8 degree

Solubility: dej huv: 20 mg / ml raws li kev daws teeb meem cia. Kev daws teeb meem cia yuav tsum tau khaws cia ntawm -20 degree. Khw ntawm 37 degree rau 3 hnub.

Acidity Factor (Pka): Pka ~ 5.7 (DMF / H2O) (tsis paub tseeb)

Daim Ntawv: Hmoov

Xim: nplaum daj

Dej Solubility:<0.1g/100mLat21ºC

Ntsoov: Yah Nom Tshuaj & Lub Teeb Txaus Ntshaw

Merck: 13,590

BNN: 78342

Stability: ruaj khov tab sis yuav rhiab rau lub teeb. Tsis sib xws nrog cov neeg muaj zog oxidants.

Inchikey: apkfdsvgjqxuky-inpoywnpsa-n

Cas database: 1397-89-3 (CASTEth Kev siv) EPA

Tshuaj lom neeg cov ntaub ntawv: AMPHOERICICEIN B (1397-89-3)

Polyene Antifungal tshuaj tua kab mob

Amphouricin B, tseem hu ua Lushanmycin, yog cov tshuaj tua kab ntsig polyene los ntawm Streptomycesnodosus. Nws yog tib qho khoom siv Lushanmycin tsim los ntawm cov khoom siv Lushlycetes, Bacillus Brasoforms, Bacillus Dermatitis, Candida Alba thiab qee tus Nocardia. MOL yog feem ntau 0. {2-0. 5 ug / ml. Cov molecular muaj pes tsawg leeg ntawm amphotricerin b yog macrolide uas muaj 7 khub ntawm mycosamine ua ib pawg qab zib, thiab yog tus qauv ntawm cov qauv ntawm cov pab pawg amino thiab pab pawg carboxyl. Cov tsos yog daj los yog txiv kab ntxwv-daj hmoov, tsw phem lossis yuav luag tsis muaj ntxhiab, noo noo-intrucing, yooj yim kom tau rhuav tshem hauv lub hnub. Nws maj mam decomposes saum 17 0} degree thiab tsis ruaj khov ntawm 37 degree. Cov. Nws yog yaj nyob rau hauv depethyl sulfoxide, me ntsis yaj nyob rau hauv methanol, thiab insoluble hauv dej, ethydrous ethanol, chloroform, lossis ether. Ntsev tuaj yeem tsim nyob rau hauv nruab nrab lossis acidic media, nws cov dej solubility nce tab sis cov tshuaj tua kab mob ua kom tsawg. Lub teeb deoxychchche ua lub teeb hmoov daj, uas tuaj yeem tsim cov tshuaj colloidal hauv dej thiab tuaj yeem siv rau kev txhaj tshuaj. Cov tshuaj lom neeg tuaj yeem tswj lub sijhawm ntev ruaj khov nyob rau hauv qhuav, tsaus thiab txias cov kev daws teeb meem, tab sis nws tuaj yeem khaws cia ntawm 4 degree rau ib lub lis piam. Cov nyhuv tua kab mob tau muaj zog tshaj ntawm ph6.0 ~ 7.5, thiab tsis muaj zog ntawm PH tsawg. Nws cov tshuaj tua kab mob tawm tsam yog tias nws tuaj yeem khi rau ergosterol ntawm fungal cell membrane, uas muaj permeability, thiab kev tuag ntawm cov tshuaj enracellular. Cov kab mob tsis muaj txiaj ntsig vim tias lawv tsis muaj ergosterol ntawm lawv cov xovtooj ntawm tes. Cov khoom no tsis yooj yim los nqus ntawm qhov ncauj lus, thiab cov ntshav ntshav zoo tuaj yeem tswj hwm rau ntau tshaj 24h tom qab Intravenous Txoj kev lis ntshav. Nws tsis yooj yim hla cov ntshav thaiv cov ntshav. AMPHOTICICEYIN B yog yuav luag rau feem ntau cov fungi, cov tshuaj tiv thaiv yeeb tshuaj muaj tsawg dua 40 xyoo, thiab cov txiaj ntsig ntawm cov txiaj ntsig tau, thiab lwm yam ntawm amphotericin b yog tsawg heev. Txhawm rau kom txo cov kev sib raug zoo, peb lub tebchaws Liposomal ntawm amposomein b tau tsim tawm txawv tsis ntev los no: amplouricin b colloidal dispersant (ABCD). Cov ntaub ntawv tshawb fawb tau qhia tias peb qhov ua cov khoom noj ntau npaum li cas txo cov tshuaj lom, uas tsis yog ua kom muaj kev ua kom cov tshuaj tiv thaiv hiav txwv, tab sis kuj ua rau kev ua tau zoo ntawm cov tshuaj.

Pharmacological txiav txim siab

AMOHOTICICICEYM B hauv cov pwm ntawm cov pwm thiab lipid Cawv (Fungi) ua ke, ua kom puas cov roj ntsha li cov amino acids, rhuav tshem cov metabolism hauv cov tshuaj lom neeg, ua kom puas hauv cov tshuaj lom neeg thiab lwm yam ntawm cov tshuaj txhuam tshuaj kev tuag. Vim tias cov kab mob cell membrane tsis muaj ergosterol, cov tshuaj no tsis txwv lossis tua cov kab mob. Ntawm cov cell ib leeg ntawm tib neeg thiab tsiaj, cov roj cholesterol yog lub ntsiab tivthaiv yog qhov tshwj xeeb nrog amphohologicin B, yog li nws muaj qee yam toxicity rau tib neeg lub cev.

Pharmaconinetics

Nws tsis zoo nqus thiab tsis ruaj khov los ntawm kev mob plab zom mov. Thaum pib ntawm kev kho, amphouricin b1 ~ 5mg tau txhaj txhua hnub, thiab cov ntshav siab} mg / l thaum nws tau nce ntxiv {}}. 65mg / kg ib hnub. Ib nrab-lub neej ntawm kev tshem tawm ntshav yog li 24 teev. Cov protein khi tus nqi yog 91% ~ 95%. Cov tshuaj concentration ntawm cov khoom no hauv cov kua dej ua kua, ascites thiab cov tshuaj synovial yog feem ntau tsawg dua li ib nrab ntawm cov zais cia hauv kev zais cia tseem tsawg. Qhov siab tshaj plaws ntawm cov khoom lag luam no tau pom nyob rau hauv lub raum nqaij, mob siab, mob ntsws, mob ntsws, lub plawv, pob txha caj qaum thiab lwm yam. Cov khoom no maj mam ua nyob rau hauv lub cev los ntawm lub raum, li ntawm 2% ntawm cov tshuaj uas tau tso tawm nyob rau hauv cov qauv tau tawm hauv cov zis tsis pub dhau 7 hnub. Kev tso zis rau hauv cov zis txuas ntxiv rau li 7 lub lis piam tom qab tshem tawm, nrog nce ntxiv cov tshuaj hauv Alkaline cov zis. Cov khoom no tsis yooj yim ntxuav los ntawm lim ntshav. Cov ntaub ntawv muab tso ua ke los ntawm kev siv tshuaj.

Kev taw tes

Amphotericin B yog thawj qhov kev xaiv rau kev kis tus kab mob fungal tob thiab muaj ntau yam pom ntawm cov tshuaj tiv thaiv kab mob antifungal. Nws muaj cov nyhwm muaj nyhuv rau cryptococcus, coccida albicans, Blastomyces, thiab lwm yam. Nws yog cov tshuaj zoo rau kev kho mob ntawm kev kis tus mob fungal tob. Lub chaw kuaj mob tseem ceeb muaj raws li nram no:

① Treatment of cryptococcosis, North American blastomycosis, disseminated candidiasis, coccidioidosis, histoplasmosis.

Kev kho mob mucocosis tshwm sim los ntawm rhizopus, plowels, endomyces thiab frogsteroids.

Kev kho cov sporotrichosis tshwm sim los ntawm sporotrichothautis shenchemicalenis.

④ Kev kho mob Aspergillosis tshwm sim los ntawm aspergillosis fumigatum.

⑤ Kev npaj ntawm lub ntsiab yog tsim nyog rau pigmentosis, daim tawv nqaij fungal tom qab hlawv cov kab mob candida, aspergillus lossis cryptococcus ulcer.

Cov cuab yeej tshuaj

Daj ntseg daj rau txiv kab ntxwv-daj siv lead ua lossis hmoov. Insoluble hauv dej, ethanol, soluble hauv acidic dmf, dmo, me ntsis soluble hauv dmf, acidic lossis alkaline-uas muaj cawv ntau. Tsis muaj ntxhiab, yuav luag tsis tau. Yooj yim rhuav tshem los ntawm lub teeb, kub thiab acid.

Kev siv

Cov khoom muaj qhov muaj zog inhibition lossis tua cov nyhuv ntawm ntau yam kab mob fungals, crypicans cryoformans, storotrichia schenckii, mucor thiab coccidioids. Nws yog tsuas yog siv raws li thawj qhov kev xaiv rau cov kab mob fungal tob.

Amphouricin B yog cov tshuaj tiv thaiv kab mob polyene. This product combines with sterols on fungal cell membrane, damages membrane permeability, leads to leakage of potassium ions, nucleotides, amino acids, etc. in bacterial cells, destroys normal metabolism and plays a antibacterial role.

Txuj Ci Ntau Lawm

Siv cov Streptomyces Nobilis lim ua qhov sib sib zog nqus tau muaj cov khoom siv ua kua roj hmab, thiab cov orgoeticin tau muab rho tawm hauv cov khoom siv ua kua thaum muaj kev sib npaug. Amphotericin muaj ob feem, ib feem yog tsawg dua cov tshuaj lom, tsis siv hauv kev siv tshuaj, tsis yog muaj zog, hu ua amphouricinin B.

Hom

Tshuaj lom neeg

Kev faib tshuaj lom

Heev toxic

Mob Toxicity

VENO - RAT LD50: 11.3 mg / kg; Peritoneal kab noj hniav - nas ld50: 27.74 mg / kg

Flammability cov yam ntxwv tsis zoo

Combillible; Cov cua sov ua rau cov tshuaj lom nitrogen oxide

Cia thiab Tsheb Thauj Tsheb

Lub Warehouse yog cua thiab qhuav ntawm qhov kub tsis qhuav

Tua Hluav Taws Extinguishing Tus Neeg Sawv Cev

Hmoov nplej qhuav, ua npuas ncauj, xuab zeb, carbon dioxide

Cov Ntaub Ntawv Kev Nyab Xeeb

Cov khoom lag luam phom sij Mark: C, XI, xn, t

Cov kev phom sij qeb code: 36/37 / 38-22-40-23 / 24/25

Cov lus qhia kev nyab xeeb: 26-36 / 37 / 39-45-36-60-37

Cov Khoom Siv Hluav Taws Xob Thauj Khoom Cai: Tsis 1759 8} / pg 3

WGK Lub Tebchaws Yelemees: 3

RTECS: BU2625000

F:8-10-21

Qib Nyab Xeeb Qib: 6.1 (b)

Pob Qeb: III

Code Code: 29419090

Cov Khoom Siv Cov Khoom Siv Cov Ntaub Ntawv: 1397-89-3 (Kev Nyab Xeeb (Chaw Nyab Xeeb

TOXICICITY: LD50inmice (MG / kg): 88I.P., 4I.V. (Kuas)

Cim npe nrov: Amphouricin B Polyene Antifungal, Tuam Tshoj Amphotericin B Polyene Antifungal Cov Khoom Siv Khoom Siv