Daunorubicin Hydrochloride yog tshuaj tua kab mob antibiotion

Englis Lub Npe: Daunorubicin Hydrochloride

Tus lej lej: 23541-50-6

Molecular cov mis: C27h29NO10.CLH

Molecular hnyav: 563.98

Einecs tus naj npawb: 245-723-4

Lwm Qeb

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Mol Cov Ntaub Ntawv: 23541-50-6. Mol

Cov Qauv Txheej Txheem:

Cov Khoom Ntawm Daunorubicin Hydrochloride

Melting taw tes: 190 Qib (Dec)

Kev sib hloov tshwj xeeb: D 20+248 ± 5 degree (c =0.}}}. 1inmethanol)

Cov xwm txheej: Inertatmosphere, 2-8 degree

Solubility: soluble hauv dej thiab methanol tshuaj lom neeg, soluble me ntsis hauv ethanol, yuav luag Insoluble hauv acetone.

Daim Ntawv: Khoom

Xim: Liab rau xim liab

Dej Solubility: SolubleMater (50mm)

Siab kawg wavelength (λmax): 477nm (H2O) (lit.)

Rhiab: Hygroscopic

Merck: 14,2832

BNN: 4229221

Ruaj khov: kev ruaj khov

Inchikey: Gughguxzjwaarna-n

Smiles: c 1= cc2c ({2} {}} @H] (c @@ h] (o) [c @}}}}}}} c (} {13} {13}} C1.Cl|& 1: 10,16,18,22,24, r |

EPA Tshuaj Xyuas: Daunorubicin Hydrochloride (23541-50-6)

Koog tsev

Daunorubicin hydrochloride, raws li ib qho kev kho mob ntawm cov kab mob helute, yog thawj cov kab mob hauv lub chaw saib xyuas kev ua haujlwm Ntxiv rau kev kho mob mob hnyav, nws kuj tseem tuaj yeem ua ke nrog prednisone, cytarabine lossis vinblastine kom nce nws cov khoom siv tawm tsam kev tawm tsam.

Xyaum Ua Me Me

Daunorubicin hydrochloride muaj cytotoxic thiab yog lub voj voog ntawm tes tsis yog cov tshuaj uas tsis paub meej. Los ntawm ntxig rau hauv lub hom phiaj cell, Daunorubicin tuaj yeem ntxig ntawm cov txheej txheem dawb, ua rau cov txheej txheem DNA ntawm nucleic acid, thiab tiv thaiv MRA Synthesis. Mus txog cov ntaub so ntswg rau cov ntaub so ntswg, nws kuj tseem tuaj yeem ua rau lub ntsej muag ntawm tes ua kom tawg, ua rau ntawm tes tuag, thiab yog li ua lub luag haujlwm.

Pharmacological txiav txim siab

Daunorubicin yog ib lub cyclide-tshwj xeeb los tiv thaiv tus neeg saib xyuas cov qog. Cov neeg tshawb nrhiav tsiaj tau pom tias nws muaj lub neej ntev L1210 leukemia, {} {{{{{{{{{{{{{{{{{}} fluoropleatant ntawm tes kab. Ib qho ntxiv, nws muaj lub neej-ntev cov nyhuv rau yoshida sarcoma nas, {{}} chlorouracil,}} chlorolil, mitomycin C thiab Chromomycin A3 resistant ntawm tes kab. Lub tshuab ntawm kev ua ntawm Daunorubicin lus dag nyob rau hauv nucleic acid synthesis txheej txheem ntawm synthesis thiab DNA RNA synthesis thiab DNA RNA synthesis cov tshuaj tiv thaiv.

Soj ntsuam daim ntawv thov

Ntxiv rau kev kho mob mob hnyav, nws kuj tseem tuaj yeem ua ke nrog prednisone, cytarabine lossis vinblastine kom nce nws cov khoom siv tawm tsam kev tawm tsam. Kev tshawb fawb tshawb nrhiav reagent, dav siv nyob rau hauv molecular biology, chaw muag tshuaj thiab lwm yam kev tshawb fawb. Rau neuroboblastoma thiab rhabidyoma.

Pharmaconinetics

Qhov kev ua kom haum ntshav thiab erythrocytes ntawm 1 {22}}} Cov neeg mob uas muaj mob leukemia (40) G / ml thiab 237μ g / g. Nws lub ntsiab metabolite hauv tib neeg yog kev haus dej cawv. Tag nrho cov nyiaj pab rau 24 teev yog (11.8 ± 5.1) Cov Lus Qhia Siv Khoom Siv%, 6.33 ± 2.93)%, Daunorubicinol (5.3 ± 2.48)%%. Nws faib ib nrab-lub neej (T1 / 2) yog 0.07 teev; Tshem tawm ib nrab-lub neej (T1 / 2) 2. {{{{}} Lub neej, ib nrab-lub neej (T1 / 2) uas yog 97.3 teev.

Kev taw tes

Daunorubicin hydrochloride yog siv rau mob myeloid leukemia thiab mob lymphoblastic leukemia, nrog rau mob mob hnyav.

Pharmacological kev ua thiab kev ua tshuab

Daunorubicin hydrochloride yog ib lub cyclide-tshwj xeeb los tiv thaiv tus neeg saib xyuas cov qog. Kev kuaj tsiaj tau pom tias nws muaj lub neej ntev L1210 leukemia, {{{{{{{{{{{5} {{}} fluoropl resistant ntawm tes kab. Ib qho ntxiv, nws muaj lub neej ntev ntev rau Yoshida Sarcoma nas, thiab tau pom qee qhov kev ua npaws, {{{{{{{{} {{} {{} {{{{{ovecomycin A3 resistant ntawm tes kab. Lub tshuab ntawm kev ua ntawm Daunorubicin lus dag nyob rau hauv nucleic acid synthesis txheej txheem ntawm synthesis thiab DNA RNA synthesis thiab DNA RNA synthesis cov tshuaj tiv thaiv.

Cov Ntaub Ntawv Kev Nyab Xeeb

Cov khoom lag luam txaus ntshai: xn, xi

Cov Txheej Txheem Kawm Txuj Ci: {22-40-42}}} {1}}}} / 21/22

Cov lus qhia kev nyab xeeb: 22-36 / 37-45-37} {2}}

Cov Khoom Siv Hluav Taws Xob Thauj Code: Tsis 2811 6. 1 / pg 3

WGK Lub Tebchaws Yelemees: 3

RTECS: HB7878000

F: 3-10

Qib Nyab Xeeb Qib: 6.1 (b)

Ntim cov III Cov Code 509419059

Toxicity LD50 hauv nas (mg / kg): 26 IV (Dimarco, 1969)

Cim npe nrov: Daunorubicin hydrochloride yog tshuaj tiv thaiv kab mob antibiotic, Tuam Tshoj Daunorubicin Hydrochloride yog tshuaj tiv thaiv kab mob antibiotic