JosamyCin yog macrolide tshuaj tua kab mob

Lub Npe Askiv: Josamycin

Tus lej lej: 16846-24-5

Cov Qauv Molecular: C42H69NO15

Molecular hnyav: 827.99

Einecs tus naj npawb: 240-871-6

Lwm Qeb

Nroj Tsuag; Macrolide tshuaj tua kab mob; Tus qauv txheeb xyuas; Kev Kawm Txuj Ci Neej Txuj Ci; Tshuaj tua kab mob; General biochemical reagents - tshuaj tua kab mob; Cov khoom tswj; Tshuaj lom neeg cov tshuaj lom neeg; Amines; Chiralreflents; Tshuaj tua kab mob; A-kantibiotics; Antibacterial; Cov tshuaj tua kab mob antibieto; Cov tshuaj tua kab mob-mantibiotics; Tshuaj lom neeg tshuaj lom neeg; Cuam tshuam nrogWithproteSinsinsYNtawm; Macrolides; Mechanismaction; Spectrumofactival; Hetercycles; Intermediates & Finchemicals; Kws Tshuaj

Mol Cov Ntaub Ntawv: 16846-24-5. Mol

Cov Qauv Txheej Txheem:

Cov Qauv Txheej Txheem:

Cov yam ntxwv ntawm LucamyCin
Melting Taw tes: 131.5 Degree
Kev sib hloov tshwj xeeb: d 25-70 degree (c =1 inethanol)
Bushing taw tes: 763.27 degree (ntxhib)
Ntse: 1.1547 (rattosestate)
Cov ntsiab lus tsis pub: 1.6220 (echemicalbictis)
Cia Yuav Tsum Koom Tes: InertatMosphere Storeinfreezer, hauv - 20 degree c
Solubility: soluble hauv ethanol
Daim Ntawv: Hmoov
Acidity coefficient (PKA): 7.1 (40% AQMethanol)
Xim: Dawb rau daj daj
Merck: 13,5286
Stability: hygroscopicit

Ua rau

Cov kev txiav txim tua kab mob yog zoo ib yam li erythromycin. Nws muaj cov kabmob tshuaj tua kab mob zoo li cov kab mob Staphyrococcus, itthratheria tshuaj ntsuab, thiab lwm yam. Muaj txiaj ntsig tawm tsam mydloplasma, chhlamydia, ricketiae thiab spelieta, thiab lwm yam kuj tiv thaiv Gram-zoo Anaerobic kab mob tshaj erythromycin.

Kev taw tes

Cov kab mob tseem ceeb ntawm cov kab mob rhiab tshwm sim los ntawm kev mob ua pa, kab mob otsisitity, tonsillontal qog thiab li ntawd. Nws kuj tseem tuaj yeem kis nrog tus kab mob staphylococcus tiv taus penicillin thiab erythromycin.

Txoj kev kuaj pom

Txoj kev tseem ceeb triodetection rau cov titer ntawm oxamycin yog lub raj thiab hom disc. Los ntawm kev siv cov nyhuv cuam tshuam ntawm cov tshuaj tua kab mob hauv cov kev paub nruab nrab, cov qauv nrog kev tsis paub txog rau cov kab mob uas muaj cov kab mob uas muaj kev nkag siab. Thaj chaw inhititics tsam yog tsim vim muaj cov kab mob inhibition, thiab qhov loj me ntawm thaj chaw inhibitosation yog ib feem ntawm cov tshuaj tua kab mob. Cov qauv no siv tshuaj tua kab mob no kom ua rau muaj cov kabmob ntawm cov kab mob rhiab, yog li nws tau lees paub thoob ntiaj teb.

Kev ua haujlwm biological

JosamyCin (en {{-141}}}, Leucomycin A3, turimycin A5) yog ntau cov kev ua haujlwm ntawm antimicrobial tiv thaiv cov kab mob ntawm cov pathogens.

Phiaj taw tes

KD: 5.5 NM (Ribosome)

Hauv kev kawm vitro

Kev tshawb fawb qhia tau tias lub neej nruab nrab ntawm tus ribosome yog 3 h rau Josycin thiab hais tias tus conpasciation conpants rau Josinycin khi rau Ribosome yog 5.5 nm. JosamyCin qeeb qeeb los tsim cov nyiaj peptide thawj zaug, nyob ntawm txoj kev muaj kuab lom, raws li interating cov protequins thib ob, synthes ntawm pulletide cov protein yog tag nrho Josycin. Ntawm kev siv tshuaj uas muaj cov tshuaj yeeb zoo, synthesis ntawm cov protelength cleins yog tag kaw los ntawm Josycin.

Hauv Vivo kawm

Cov ntshav thiab cov nqaij theem ntawm josamycin tom qab kev tswj hwm ntawm qhov ncauj yog 200 mg / kg rau luav. Cov qib nqaij feem ntau yog feem ntau ntau dua li cov ntshav siab, thiab 3 h tom qab cov ntshav tsawg dua, cov nqaij muaj ntau dua li cov 1 h tom qab cov koob tshuaj. Ib teev tom qab tshuaj noj, qib hauv lub ntsws yog qhov siab tshaj plaws ntawm txhua daim ntaub.

Cov Ntaub Ntawv Kev Nyab Xeeb

WGK Lub Tebchaws Yelemees: 2

RTECS: OH4725810

F: 10

Kev lom zem: LD50 hauv cov nas:> 7GM / kg

Cim npe nrov: Josinycin yog macrolide tshuaj tua kab mob, Suav JosamyCy yog ib lub macrolide tshuaj tua kab mob