Cov khoom lag luam
Hmong npe: Nystatin
Tus lej lej: 1400-61-9
Molecular Cov Qauv: C47H75No17
Molecular hnyav: 926.09
Einecs tus naj npawb: 215-749-0
Lwm Qeb
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Mol Cov Ntaub Ntawv: 1400-61-9. Mol
Cov Qauv Txheej Txheem:
Nystatin cov khoom lag luam
Melting point: >155 degree (dec.)
Kev sib hloov tshwj xeeb: d {{0}} degree (glacialacid); +21 degree (pyridine); +12 degree (dmf); 7 Degree Nhclinmethanol (0.1)
Kev mob cia: -20 degree
Solubility: insoluble hauv dej
Acidity coefficient (pKa) : pKaChemicalbook5.72(MeOH/2-methoxyethanol/H2O)(Uncertain); 8.64 (tag nrho cov)
Daim Ntawv: Ncua Sijhawm
Xim: nplaum daj
Cov ntxhiab: Cov ntxhiab tsw qoob loo
Tau qhov los ntawm: Streptomycesnoursei
Dej Solubility: 0. 36g / l (24ºC)
Merck: 13,6770
Cov haujlwm tshwj xeeb: ntau dua los yog sib npaug rau 4,400USp units / mg
BCS chav kawm: 3
Inchikey: VxwfktggegLhpp-oqmkpjefsa-n
CAS database: 1400-61-9 epa
Cov ntaub ntawv siv tshuaj: Nystatin (1400-61-9)
Siv thiab synthesis ntawm nystatin
Polyene Antifungins
Nystatin yog hom panyene antifungicin nrog conjugated qauv, uas tuaj yeem siv rau cov tshuaj lom neeg tsis muaj tus kab mob. Nyystatin khi rau Sterols ntawm fungal cell weepbranes thiab ua rau cov kev hloov cell mem kab ntawv, ua rau lub luag haujlwm tseem ceeb ntawm lub luag haujlwm thiab ua lub luag haujlwm antifungal.
Nystatin muaj ntau daim ntawv thov, xws li tiv thaiv kev coj ua kev coj ua kev cai coj ua tsis huv Nyystatin yog siv los ua fungal membrane (ergosterol khi) pore-ua rau tus neeg sawv cev thiab tsim NYSTatin / P-ion raws li Lipid Bilayer.
Nystatin, raws li cov neeg muaj fungal inhibitor, feem ntau yog siv los npaj cov xov xwm xaiv.
Nystatin tuaj yeem siv tau hauv cell kab lis kev cai nrog kev pom zoo ua haujlwm ntawm 0. 05mg / ml. Nws tau ua tau zoo inhibition nyhuv thiab ruaj khov ntawm 37 degree rau 3 hnub. 50mg / ml tshem tawm tuaj yeem npaj ua cov tshuaj cia thiab khaws cia ntawm -20 degree. Kev kub siab lossis pom kev tsis pom zoo.
Cov tshuaj tua hluav taws
Nystatin muaj cov tshuaj tua kab mob muaj zog tiv thaiv Candidans, Aspergillus Cloice, cocophyton, cocophoides, boccidyces, bulastomyces dermatitis, dermatophton thiab lwm yam.
Lub cev thiab tshuaj
Daj lossis daj daj hmoov hmoov, nrog cov ntxhiab tsw tshwj xeeb thiab noo noo-ua cov khoom. Soluble me ntsis hauv dej, methanol, ethanol, insoluble hauv acetone, ether thiab chloroform. Nystatin tsis ruaj khov rau huab cua, lub teeb, kub, dej, kua qaub lossis puag lossis hauv paus.
Xyaum Ua Me Me
Nystatin tuaj yeem khi rau cov sterols ntawm cov tshuaj fungal cell, kom cov tshuaj lom neeg hloov pauv, yog li ua rau lub luag haujlwm antifung.
Ua ntaub ntawv
Nystatin, tseem hu ua Nyystatin, Micodin, Crycor thiab microspora nkag siab zoo rau tus kws kho mob cov lus qhia kom siv cov tshuaj.
Pharmaconinetics
Nyystatin tsis nqus los ntawm cov plab zom mov tom qab cov kev tswj hwm tom qab qhov ncauj, thiab tsis nqus tau ntawm daim tawv nqaij thiab mucosa rau kev siv tshuaj pleev hauv zos. Yuav luag tag nrho cov koob tshuaj yog excreted los ntawm cov quav hauv nws daim ntawv qub. Cov tswj hwm hauv zos rau kev kho mob candidiasis, 24 txog 72 teev tom qab qhov siab tshaj plaws.
Kev siv
Nystatin ntsiav tshuaj muaj qhov dav dav ntawm cov tshuaj tiv thaiv kab mob, thiab cov kab mob istibratis zoo ib yam li cov tshuaj tua kab mob, cov tshuaj tua kab mob ntawm cov kab mob thiab cov tshuaj tua kab mob, Blastomyces dermatitis thiab dermatophton. Lawv feem ntau yog siv rau Candida Albicans raug mob ntawm daim tawv nqaij mucosa, qhov ncauj thiab chaw mos.
Cov cuab yeej tshuaj
Daj lossis daj daj hmoov hmoov, nrog cov ntxhiab tsw tshwj xeeb thiab noo noo-ua cov khoom. Soluble me ntsis hauv dej, methanol, ethanol, insoluble hauv acetone, ether thiab chloroform. Nws tsis ruaj khov rau huab cua, lub teeb, kub, dej, kua qaub lossis alkali. Antifungal tshuaj tua kab mob.
Kev siv
Nystatin yog cov antifungal antifungal tshuaj tua kab mob nrog cov pro-inflamatory yam ntxwv. Nws muaj ntau cov ntawv thov, xws li tiv thaiv kev coj noj coj ua ntawm tes ua paug thiab ua rau muaj kev sib kis ntawm tes ntawm no) Nws yog siv los ua fungal membrane (ergosterol khi) pore-ua rau tus neeg sawv cev thiab tsim NYSTatin / P-ion raws li Lipid Bilayer.
Cov tshuaj antifungal tshuaj muaj peb cov khoom xyaw bioactive: A1, A2, thiab A3, nrog cov muaj zog pro-biroamatory muaj zog. Nws yog tsuas yog siv rau Candida Albicans muaj kab mob ntawm daim tawv nqaij, qhov ncauj, hnyuv, thiab muaj cov nyhuv bactericidal hauv siab.
Cov Ntaub Ntawv Kev Nyab Xeeb
Cov khoom lag luam txaus ntshai: F, C
Kev Nyab Xeeb Nqe Cai: 11-34
Cov Lus Qhia Kev Nyab Xeeb: 22-24} / 25-45-36 / 37 / {3}}
WGK Lub Tebchaws Yelemees: 3
RTECS: RF5950000
F : 10-8-23
Chav Nyab Xeeb: 3
Code Code: 382110000
Cov tshuaj muaj kev phom sij: 1400-61-9 (cov khoom muaj kev phom sij)
TOXICICITY: LD50 IP nyob rau hauv Mice: ~ 200 kg (Seneca)
Cim npe nrov: Nyystatin yog Antifungal Tus Neeg Sawv Cev, Tuam Tshoj Nystatin yog tus neeg sawv cev Antifungal tus neeg muag khoom
