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Oseltamivir kev kho mob phosphate rau kabmob npaws a thiab b

Oseltamivir kev kho mob phosphate rau kabmob npaws a thiab b

English Lub Npe: Oseltamivir Phosphate
Tus lej lej: 204255-11-8
Lwm Lub Npe: Osteltamivir Phosphate; (3R, 5s) {} {} {} {}}}}}} E6} E6} EX} E6} E6} E6} E6} E6} E6} E6} E6} E6} E6} E6} E6} E6} E6} E6} E6} E6} E6} EXE} EXE} EXE} EXE} EX} EXE} EXE} EXE} EXE} EXE} EXE} EXE} EXE} EXE} EXE} EXE} EXE} EXE} EXE} EX} phosphat; Oseltamivir phosphate (200 mg); Oseltamivir acid-d3 phosphate; eseltamivir phosphate (tamifllu); (3r, 4s) -ethyl 4- acetamido {16} {{17} {17} -1- enecarboxylate phosphate
Xa kev nug

Cov khoom lag luam

 

English Lub Npe: Oseltamivir Phosphate

Tus lej lej: 204255-11-8

Molecular cov mis: c16h31n2o8p

Molecular hnyav: 410.4

Einecs tus naj npawb: 616-396-9

Lwm yam khoom: Cov ntaub ntawv raw; Tshuaj tua kab mob; Tshuaj Nruab Nrab Hluav Taws Xob; Cov ntaub ntawv rawcuitical; Los tiv thaiv khaub thuas tshuaj rau kev siv kho tsiaj; Cov ntaub ntawv rawcuitical; Cov me me molecule inhibitor; Cov kab mob tsis sib haum xeeb; Tshuaj lom neeg nruab nrab; Kws Tshuaj Kho Mob thiab Kev Lag Luam; API; Tamiflu; Cov khoom siv raw; Antifungal antiviral; Kev tshawb xyuas cov tshuaj tiv thaiv - cov khoom siv; Cov khoom lag luam qauv - Suav tshuaj cov khoom lag luam; Cov khoom xyaw; Tshuaj nplua cov ntaub ntawv; Cov kab mob tsis sib haum xeeb; Cov Khoom Siv Raw Tshuaj; Tshuaj lom neeg cov tshuaj lom neeg; Organic intermediates; Antiviral; Tshuaj tua kab hluav taws xob; Nruab nrab nruab nrab; Cov tshuaj hauv tsev; Mekas; Cov Khoom Siv Raw Tshuaj; Oseltamivir phosphate cov khoom siv; Cov khoom tswj; Intermediates & Finchemicals; Kws muag tshuaj; Ringsystems; Oseltamivir; Ua txhaum; Amines; Anti-virals; nyob apis

Mol Cov Ntaub Ntawv: 204255-11-8. Mol

 

Cov Qauv Txheej Txheem:

1 -

 

Cov khoom ntawm Oseltamivir Phosphate

Melting taw tes: 196-198 degree

Kev Cia Mob Cia: 2-8 degree

Solubility: H2O: Soluble, 30mg / ml, qhia meej

Daim Ntawv: Hmoov

Xim: Dawb rau beige

Kev ua kho qhov muag: [] / d -26 rau -36 degree, c {{in inst2o

Dej Solubility: SolubleMater (75mm)

BCS Class1: (Clogp), 3 (logp)

Inchi: Inchi {=1 / c16h28n2o4.h3o4p / c}} ({{} {{{{{17 (14) {17}} (4) 19 ; {1-5 (2,3) 4 / h9} h3 ,, 14+}}}}; / s3

Inchikey: PgzumbjqjjjwiwGJ-iFakauozsa-n

Luag: [C @@ H] 1 (CC) CC) CC) CC) CC)

CAS database: 204255-11-8 (CASTE)

 

Siv thiab synthesis txoj kev ntawm oseltamivir phosphate

 

Ua ntaub ntawv

Oseltamivir phosphate yog cov tshiab neuraminidase (na) inhiboritor, mob khaub thuas thiab kev tiv thaiv tus kab mob khaub thuas siab thiab nyhav kom tsis txhob mob khaub thuas ua npaws A thiab B. Oseltamivir tau teev nyob rau hauv Switzerland hauv xyoo 1999, thiab muaj ntau cov kev kuaj mob muaj pov thawj, cov neeg mob qis, thiab siv tau dav hauv chaw kuaj mob thiab kho mob khaub thuas.

 

Cov tshuaj tiv thaiv tus tshuaj ua npaws

Oseltamivir phosphate yog cov tshuaj tiv thaiv khaub thuas tamiflue (tamsis no los tiv thaiv tus kabmob daj ua npaws, ntawm kev tswj cov tsos mob khaub thuas. Nws yog lub tsev kho mob A thiab B hauv cov neeg laus thiab menyuam yaus 1 xyoos thiab laus dua, thiab cov tub ntxhais hluas thiab laus dua. Oseltamivir phosphate yog nrawm dua rau Oseltamivir carboxylate tom qab nqus tau pa. Yam tsawg kawg 75% ntawm qhov ncauj siv tau koom nrog hauv kev ncig ua si raws li oseltamivir carboxylate. Cov khoom xyaw nquag ntawm oseltamivir phosphate yog lub zog thiab tshwj xeeb neuraminidase inhibitor uas ua rau txhua theem ntawm tus kab mob tus kab mob khaub thuas. Thaiv cov kev rov ua dua ntawm txhua lub tsev kho mob uas muaj feem cuam tshuam nrog tus kab mob npaws Cov cuab yeej ua haujlwm nquag tau pom tias yuav ua rau muaj kev sib kis tus kab mob khaub thuas hauv cov kab mob khaub thuas, thiab ua rau muaj tus kab mob ua npaws ntawm tus kab mob khaub thuas hauv vivo. Cov khoom no txo ​​tus mob khaub thuas A lossis B tus kab mob los ntawm kev txwv tus kab mob tawm ntawm cov hlwb kis.

 

Pharmacological txiav txim siab

Oseltamivir phosphate yog cov tshuaj ua ntej ntawm nws cov metabolite, uas (Oseltamivir Carboxylate neuraminidase inhibitor. Neuraminidase yog glycoprotase ntawm cov kab mob uas nws cov haujlwm tseem ceeb rau cov kab mob hlwb uas muaj kis tau tus mob cell me me hauv tib neeg lub cev. Cov cuab yeej siv nquag ntawm cov khoom no tuaj yeem cuam tshuam cov kev ua tus mob neuraminidase ntawm tus mob khaub thuas A thiab B viruses tsim los ntawm kev tsim tawm. Cov conceptur ntawm ib nrab ntawm viral neuraminidase kev ua si hauv vitro tau tsawg li nanoegrams (ng). Cov cuab yeej ua haujlwm nquag tau pom tias yuav ua rau muaj kev sib kis tus kab mob khaub thuas hauv cov kab mob khaub thuas, thiab ua rau muaj tus kab mob ua npaws ntawm tus kab mob khaub thuas hauv vivo. Cov khoom no txo ​​tus kis tus mob khaub thuas A lossis B BE B los ntawm kev tso tawm tus kab mob tawm los ntawm cov hlwb kis.

 

Kev taw tes

Oseltamivir phosphate yog qhia txog kev kho mob npaws ntawm tus mob khaub thuas a thiab b, tab sis cov khoom siv tshuaj tua kab mob npaws cuam tshuam); Rau kev tiv thaiv tus mob khaub thuas A thiab B hauv cov neeg laus thiab cov hluas hnub nyoog 13 xyoos thiab laus dua.

 

Kev ua haujlwm biological

Oseltamivir phosphate yog muaj zog thiab xaiv cov khoom seem ntawm cov neuraminidase tseem ceeb rau kev replication ntawm tus mob khaub thuas A thiab B tus mob rau kev kho mob khaub thuas.

 

Phiaj taw tes

Lub Hom Phiaj

Neuraminidase

 

Kev siv

Cov tshuaj tua kab mob thiab tshuaj tua kab mob

 

Cim npe nrov: Kev kho mob oseltamivir rau kev mob khaub thuas A thiab B, Tuam Tshoj Oseltamivir kho mob phosphote rau kabmob npaws thiab tus neeg muab khoom