Cov khoom lag luam

Lus Askiv Lub Npe: Polymyxin B sulfate

Tus lej lej: 1405-20-5

Molecular cov mis: C56H100N16o17S

Molecular hnyav: 1301.56

Einecs tus naj npawb: 215-774-7

Lwm Qeb

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Mol Cov Ntaub Ntawv: 1405-20-5. Mol

Cov Qauv Txheej Txheem:

1 -

Polymyxin B Cov Khoom Siv Sulfate

Melting taw tes: {217-220 degree (Dec.)

Kev Cia Siab: {{2-8 degree solubility H2O: 50MG / ML

Acidity Factor (PMA): PKA8.9 (tsis paub tseeb)

Daim Ntawv: Hmoov

Xim: tsis muaj kob lossis daj

P nqi: pH (1 0 g / l, 25 degree): 4.5 ~ 7.0

Optical sib hloov (tshuaj lom neeg): [Alpha] / d20 / d (kev sib hloov: 2. {- 0. 2 degrees)

Keeb kwm: Pseudomonaseruginosa

Dej Solubility: Solubleinwaterat50mg / ml / n

Merck: 14,7573

Stability: hygroscopicity

Inchikey: Hfmdluquexnbop-UhfffaOysa-N

Logp: -6. 34 (EST)

Cas database: 1405-20-5 (CASTEth Kev siv) EPA

Tshuaj Xyuas Cov Ntaub Ntawv: Polymixin B sulfate (1405-20-5)

Daim Ntawv Thov thiab Synthesis ntawm Polymyxin B Sulfate

Kev taw tes

Polymyxin B sulfate, zoo ib yam li Polymyxin E, muaj cov kab mob Escherico, xws li cov kab mob Escherice, partussis bacillus thiab dysenty bacillus. Nws yog tsuas yog siv rau qhov txhab, tso zis, lub qhov muag, pob ntseg, tachea thiab lwm tus mob astewomonas thiab lwm yam tshuaj ntsuab, thiab tseem siv tau rau sepsis thiab peritonitis. Thiab tsis kam mus rau aminoglycoside, peb tiam cepharosporin thiab pseudomonas aeraremia, xws li kab mob uas tsis muaj mob, xws li kis tus kab mob, tom qab tawg, thiab lwm yam.

Kev siv thiab ntau npaum li cas

Lub cev ntaj ntxiv: cov neeg laus thiab cov menyuam yaus uas tau txais lub raum zoo li qub 1 thiab ntau dua 2.5mg ntawm lub cev hnyav (feem ntau tsis muaj ntau dua 2.5mg ntawm lub cev hnyav), muab faib ua 2 zaug 12 teev ntawm cov tshuaj mis. Rau txhua 50mg ntawm cov khoom no, dilute 500ml nrog 5% kev daws teeb meem zoo thiab poob. Cov menyuam mos uas muaj raum ua haujlwm tuaj yeem zam lub cev txhua hnub ntawm 4mg ib phaus phaus.
Intramuscular nco: Cov neeg laus thiab cov menyuam yaus: 2. {{{1} m kilogram ntawm lub cev hnyav ib hnub, muab cov tshuaj faib ua ke, ib zaug txhua {teev. Menyuam mos 1 hnub tuaj yeem siv tau rau 4MG ntawm lub cev hnyav, tshiab yug tuaj yeem yog li 4.5mg ib phaus lub cev.
Kev Txhaj Tshuaj Tshuaj (rau pseudomonas Aeruginosa meningitis meningitis): sodium tshuaj chloride txhaj tau npaj nrog 5mg ib lub millatiter ntawm cov kua dej. Cov neeg laus thiab cov menyuam yaus hnub nyoog tshaj 2 xyoos, 5mg txhua hnub, hloov mus rau 4 hnub, kom txog rau thaum Cerebrospinal Fluonations tsis zoo, cov ntsiab lus ntawm cov piam thaj tsis zoo. Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, 2mg ib zaug ib hnub rau 3 txog 4 hnub (lossis 2.5mg ib zaug txhua lwm hnub kom txog thaum qhov kev xeem yog li qub.
Qhov kev xav ntawm qhov muag poob yog 1-2. 5 mg ib ib txhiab txhiab.

Kev sib cuam tshuam yeeb tshuaj

Zam kev sib xyaw ua ke nrog kev puas tsuaj ntau dua rau lub raum, xws li entastranes, thiab lwm yam ntawm cov khoom noj kom zoo nkauj (Magnes), thiab lwm yam ntawm sulfonamide Txog kev kho mob ntawm cov tshuaj yeeb hnyav-tiv taus gram-tsis muaj tus kab mob tsis zoo, cov nyhuv yog qhov zoo dua li ntawm daim ntawv thov.

Cov teeb meem xav tau mloog

1, Cev xeeb tub thiab lactating poj niam, menyuam yaus, puas tsuaj rau lub raum pom cov neeg mob hnyav uas muaj kev ceev faj lossis txo qis.

2, Cov khoom lag luam no muaj txiaj ntsig ntau, cov nyhuv tsis zoo ntawm kev kis tau tus mob tob tob, tsis yog thawj qhov kev xaiv rau ib tus mob.

3. Kev txhaj tshuaj ntxiv yuav ua rau ua pa kev nyuaj siab thiab feem ntau tsis siv. Tsawg kawg yog ib nrab ntawm cov koob tshuaj txhua hnub yuav tsum tau muab cov tshuaj txhua hnub uas yuav tsum tau lees paub thiab yuav tsum tsis txhob raug tswj kom tsis txhob muaj ib zaug kom zam dhau kev ntxhov siab neuromuscular thaiv.

4. Nws yuav tsum tsis txhob ua ke nrog lwm cov tshuaj nrog rau lub raum lom lossis neuromuscular thaiv cov nyhuv kom tsis txhob muaj kev huam yuaj.

Kev siv

Kev Tshawb Fawb Biochemical

Polymyxin B yog tshuaj tua kab mob peptide tiv thaiv cov kab mob gram-tsis zoo. Nws tuaj yeem hloov cov qauv membrane kom cov roj me me thiab inhibit txoj kev loj hlob ntawm gram-tsis zoo cov kab mob. Nws muaj cov kab mob ua rau cov nyhuv ntawm Escherichia coli. Lipid ib feem uas khi rau cov kab mob lipidopolysaccharides. Induces lub qhov me me hauv lub ntsej muag sab nraud. Hom kev nqis tes ua: khi thiab cuam tshuam nrog cov permeability ntawm ntshav memma. Cov kab mob tua kab: Gram-tsis zoo cov kab mob.

Cov Ntaub Ntawv Kev Nyab Xeeb

Cov khoom lag luam txaus ntshai: xn

Kev Nyab Xeeb Qeb Code: 22

Cov Lus Qhia Kev Nyab Xeeb: 22-24} / 25

Cov Khoom Siv Hluav Taws Xob: 3249

WGK Lub Tebchaws Yelemees: 3

RTECS: TR1150000

F:3-8-10

Code Code: 29419000

Qib Nyab Xeeb Qib: 6.1 (b)

Pob Qeb: III

TOXICATION: Aub, Ldlo, intracreral, 32 {}}}}}}}}}}}} V. 23, pg. 552, 1964.